QTLs Influencing Immobility Times in the Forced Swim Test and Tail Suspension Test
| Nearest marker | Peak position (cM) | Peak Iod score | % Variance | Mean immobility time, sec ± se (n) | Lod score by model (% variance) | |||
| Forced swim test | B6/B6 | B6/C3 | C3/C3 | Additive | Dominant | |||
| D6Mit289 | 47.5 | 2.8 | 3.0 | 158 ± 4 (155) | 151 ± 3 (268) | 165 ± 3 (127) | — | 2.4 (2.5) |
| D8Mit242 | 51.0 | 4.2 | 5.4 | 165 ± 4 (139) | 157 ± 3 (271) | 147 ± 3 (150) | 4.2 (5.0) | — |
| D8Mit93 | 65.7 | 3.0 | 4.0 | 164 ± 4 (143) | 156 ± 3 (275) | 148 ± 3 (141) | 3.0 (3.7) | — |
| D11Mit271 | 20.4 | 3.7 | 2.9 | 167 ± 4 (173) | 151 ± 3 (278) | 155 ± 4 (134) | — | 2.6 (2.1) |
| D17Mit185 | 35.0 | 2.9 | 2.2 | 161 ± 4 (141) | 159 ± 2 (282) | 144 ± 4 (134) | 1.8 (0.6) | — |
| Tail suspension test | ||||||||
| D4Mit203 | 68.1 | 3.5 | 3.8 | 202 ± 8 (161) | 178 ± 6 (266) | 173 ± 9 (111) | 3.0 (4.6) | — |
| D8Mit242 | 44.4 | 2.9 | 2.5 | 170 ± 8 (139) | 181 ± 6 (271) | 206 ± 9 (150) | 2.8 (2.3) | — |
| D11Mit271 | 22.8 | 3.6 | 3.2 | 214 ± 9 (137) | 176 ± 6 (278) | 173 ± 9 (134) | 2.6 (4.4) | — |
| D14Mit257 | 25.1 | 3.0 | 2.3 | 178 ± 9 (151) | 176 ± 6 (271) | 211 ± 9 (129) | 1.4 (0.3) | — |
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QTLs were detected by compsite interval mapping using theCARTOGRAPHER software package, and peak lod score (% variance) was calculated by using a free genetic model. Peak position shows the distance from the centromere estimated by marker recombination (data from Whitehead Institute/MIT Center for Genome Research) and the distance between the peak and marker positions (calculated by CARTOGRAPHER). % Variance accounted for by each QTL was calculated using the same software (r 2). Additive and dominant (with respect to the C3 allele) models were also tested, and the lod scores (% variance) of the better-fit model (highest lod score) are shown. se, standard error.
