Identification of Multiple Genetic Loci Linked to the Propensity for “Behavioral Despair” in Mice

Table 1.

Summary of the Immobility Times for F0, F1, and F2 Mice

Strain/Cross Sex Immobility time, seconds ± sd (n)
Forced swim test (FST) Tail suspension test (TST)
C57BL/6 (B6) male 206 ± 32 (19) 211 ± 46 (8)*
DBA/2 male 124 ± 30 (20) 122 ± 66 (6)
BALB/c male 144 ± 21 (22) 88 ± 66 (8)
C3H/He (C3) male 103 ± 15 (20) 68 ± 28 (8)*
C57BL/6 (B6) male 194 ± 44 (63) 243 ± 72 (62)
female 181 ± 46 (63) 212 ± 86 (60)
C3H/He (C3) male 103 ± 20 (63) 64 ± 51 (60)
female 114 ± 25 (61) 60 ± 70 (61)
F1 (B6 × C3) male 158 ± 30 (63) 162 ± 77 (63)
female 162 ± 30 (63) 184 ± 69 (61)
F2 male 151 ± 41 (260) 181 ± 98 (260)
female 161 ± 43 (300) 188 ± 103 (300)
F2 total 156 ± 42 (560) 185 ± 101 (560)
  • In each animal strain or cross, age did not influence immobility times in the FST and TST between the ages of 8 and 11 weeks. All the data in this table were obtained from 8- or 9-week-old animals. sd, standard deviation; n, number of animals; B6, C57BL/6; C3, C3H/He.

  • Significantly different (P < 0.001) between B6 and C3 strains by Bonferroni/Dunn test.

This Article

  1. Genome Res. 12: 357-366

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