High-Throughput Imaging of Brain Gene Expression

Table 3.

Genes Differentially Expressed in Normal and Alzheimer's Hemisections

Miscellaneous (12 genes)
IDI1 (isopentenyl-diphosphate δ isomerase) (cholesterol synthesis)
DNC1 (intermediate chain 1 of cytoplasmic dynein) (cytoplasmic transport)
KIAA0069 (ADP-ribosylation factor-like 6 interacting protein)
SMS (spermine synthase)
DSCR1L1 (thyroid hormone-responsive gene similar to Down syndrome critical region gene)
RARS (arginyl-tRNA synthetase)
PSCA (prostate stem cell antigen)
LIMS1 (LIM and senescent cell antigen-like domains 1)
BICD1 (Drosophila Bicaudal D homolog) (cytoskeletal mRNA sorting)
XPO1 (exportin 1) (export of proteins and RNA from the nucleus)
PSCD2 (Pleckstrin homology, Sec7 and coiled/coil domains 2, cytohesin-2)
RAB2 (G protein involved in secretion)
Transcription (eight genes)
DRAP1 (DR1-associated protein 1 -ve cofactor 2 α) (transcription repressor)
NFATC3 (nuclear factor of activated T-cells, 3) (transcription factor)
ZNF142 (zinc finger protein)
KIAA1041 (forkhead domain)
TIF1α (kinase and transcription silencing factor with a RING finger)
SALL2 (zinc finger protein and homolog of the Drosophila spalt gene)
TAF2F (TAFII55) (TATA box binding protein (TBP)-associated factor 2F)
NR113 (nuclear receptor subfamily 1, group 1, member 3) (MB67, CAR-beta)
Signal transduction (five genes)
YWHAH (14-3-3 eta chain) (signal transduction)
PTPRN2 (receptor-type protein tyrosine phosphatase IA-2 beta) (signal transduction)
RAP2A (RAS oncogene family member) (signal transduction)
PRKCB1 (Protein kinase C, β1 subunit) (signal transduction)
MAPK10 (mitogen-activated protein kinase 10) (signal transduction)
Modulation cytoskeleton (three genes)
ICAP-1A (β1 integrin cytoplasmic domain-associated protein)
KIAA0992 (palladin) (localized to stress fibers and cell adhesions)
WASF1 (Wiskott-Aldrich syndrome protein family, member 1) (WAVE)
Respiration (two genes)
COX7B (cytochrome c oxidase subunit VIIb) (electron transport)
IDH3A (α subunit of mitochondrial NAD+ specific isocitrate dehydrogenase 3) (respiration)
Redox (two genes)
SEPW1 (selenoprotein W1) (redox-related processes)
CCScopper chaperone for superoxide dismutase (interacts with SOD1)
Novel (two genes)
LOC51235 (novel)
LOC51628 (novel)

This Article

  1. Genome Res. 12: 244-254

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