Putative regulatory elements shared between groups of correlated and anticorrelated genes. There were three groups of correlated (+) genes: (1) RAB2, ABCA4, BAP1, RNPS1, (2) U5-100K, LRP6, (3) ECHS1, TBXAS1; and three groups of anticorrelated (−) genes: (1) BAP1, MSX2 (2) RNPS1, U5-100K (3) LRP6, TAF2F. The groups are indicated by square brackets. The regulatory sequences responsible for correlated expression are shown as squares, those responsible for anticorrelated expression are shown as diamonds. Genes are indicated by UniGene symbol or name (http://www.ncbi.nlm.nih.gov/UniGene). Exons are indicated by short vertical lines. Lines delineate the relationships between the conserved regulatory sequences. Multiple control regions frequently connected the genes. Sometimes these control regions were found in introns or flanking regions of adjacent genes. In that case, where there was a Drosophila ortholog of the relevant gene, the control region was conserved in the Drosophila genome but in a different context. Potential binding sites are: (1) OCT-1, (2) HFH8, (3) TFIID, (4) AP1, (5) IK2, (6) Sp1, (7) USF, (8) MYOD, (9) GKLF, (10) IK1, (11) HFH3, (12) XFD1, and (13) AP4.
