Positional Candidate Cloning of a QTL in Dairy Cattle: Identification of a Missense Mutation in the Bovine DGAT1 Gene with Major Effect on Milk Yield and Composition

Table 1.

Effect of the DGAT1 K232A Mutation on Sires' Daughter Yield Deviations (DYDs) for Milk Yield and Composition

Trait α/2 ± 2std.err. r Formula PvalueQTL r Formula r Formula
Milk yield (kgs) −158 ± 24.5 0.18 5.00E − 35 0.49 0.32
Fat yield (kgs) 5.23 ± 0.9 0.15 1.57E − 29 0.55 0.30
Protein yield (kgs) −2.82 ± 0.7 0.08 1.70E − 15 0.65 0.26
Fat (%) 0.17 ± 0.012 0.51 4.33E − 122 0.29 0.19
Protein (%) 0.04 ± 0.006 0.14 5.05E − 28 0.66 0.20

  • (i) α/2: QTL allele substitution effect on DYD (≈ halve breeding value), corresponding in the mixed model to the regression coefficient on the number of K alleles in the DGAT1 K232A genotype, and to α/2, where α is defined according to Falconer and Mackay 1996. (ii)r Formula : proportion of the trait variance explained by the DGAT1 K232Apolymorphism. (iii) P valueQTL: statistical significance of the DGAT1 K232A effect. (iv)r Formula : proportion of the trait variance explained by the random, polygenic effect in the mixed model. (v)r Formula : proportion of the trait variance unexplained by the model.

This Article

  1. Genome Res. 12: 222-231

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