Table 2.
Relative Transcript Number of 75 Genes in Endobronchial Biopsy Homogenates of Asthmatic and Healthy Subjects
| Gene name | NCBI accession no. | Asthma | Non-asthma | Ratio | Pvalue |
| Cytokines IL18 | NM_001562.1 | 1.09E+10 | 2.24E+10 | 0.49 | 0.0008 |
| IGF1 | M29644.1 | 8.24E+09 | 1.54E+10 | 0.54 | 0.003 |
| IL5 | X04688 | 1.55E+09 | 3.95E+06 | 39.30 | 0.007 |
| IL13 | X69079 | 1.46E+07 | 2.03E+06 | 7.19 | 0.007 |
| IL14 | L15344.1 | 1.07E+08 | 2.20E+07 | 4.84 | 0.03 |
| IL15 | U14407 | 1.90E+08 | 3.67E+07 | 5.18 | 0.07 |
| IL16 | NM_004513 | 2.36E+10 | 3.65E+10 | 0.65 | 0.09 |
| IL8 | XM_003501 | 1.86E+09 | 3.99E+08 | 4.67 | 0.1 |
| IFNγ | NM_000619 | 2.55E+09 | 3.52E+09 | 0.72 | 0.16 |
| IL12B | NM_002187.1 | 6.48E+06 | 2.24E+06 | 2.90 | 0.18 |
| IL17 | NM_002190 | 1.12E+08 | 5.01E+07 | 2.24 | 0.21 |
| IL3 | XM_003752 | 1.02E+06 | 1.43E+05 | 7.14 | 0.23 |
| IL10 | M57627 | 4.22E+07 | 1.39E+07 | 3.03 | 0.24 |
| IL4 | NM_000589 | 4.24E+05 | 1.90E+06 | 0.223 | 0.38 |
| IL factor (IK) | S74221.1 | 493E+10 | 4.30E+19 | 1.15 | 0.4 |
| IL9 | X17543 | 1.17E+06 | 3.13E+00 | 3.7×105 | 0.41 |
| IL12A | XM_003121 | 5.25E+08 | 6.16E+08 | 0.85 | 0.77 |
| Receptors | |||||
| IL13RA2 | Y08768.1 | 2.45E+04 | 8.12E+02 | 30.15 | 0.001 |
| IL13RA1 | U62858.1 | 1.99E+07 | 7.65E+06 | 2.65 | <0.001 |
| IL4Rα | X52425 | 1.43E+07 | 3.06E+06 | 4.68 | 0.02 |
| IFNGR2 (IFNG-AF1) | U05877.1 | 2.22E+09 | 7.97E+08 | 2.79 | 0.02 |
| IL8Rb (CXCR2) | M73969.1 | 5.96E+06 | 1.20E+07 | 0.50 | 0.02 |
| IL9Ra | NM_002186 | 1.14E+06 | 1.57E+05 | 7.29 | 0.03 |
| IL10R | U00672.1 | 6.38E+06 | 2.92E+06 | 2.19 | 0.10 |
| CXCR4 | AF025375 | 2.02E+08 | 3.16E+08 | 0.64 | 0.10 |
| IL12R | U03187 | 3.18E+07 | 5.71E+06 | 5.56 | 0.12 |
| IGF1R | X04434.1 | 8.88E+06 | 3.80E+06 | 2.34 | 0.16 |
| IFNGR | J03143.1 | 1.36E+08 | 9.05E+07 | 1.50 | 0.21 |
| CCR3 | NM_001837 | 8.92E+05 | 6.65E+05 | 1.34 | 0.27 |
| CSF1R | X03663.1 | 9.60E+06 | 1.64E+07 | 0.58 | 0.29 |
| IL18R | NM_003855 | 2.73E+06 | 9.79E+05 | 2.79 | 0.32 |
| CD40-associated protein(TRAF3) | U15637.1 | 1.89E+09 | 1.05E+09 | 1.81 | 0.32 |
| Interleukin 1 receptor-like 1(T1/ST2) | NM_003856 | 4.66E+09 | 3.34E+09 | 1.39 | 0.42 |
| PDGFR | J03278 | 1.33E+07 | 9.60E+06 | 1.39 | 0.42 |
| IL8Ra | L19591 | 2.84E+05 | 2.57E+05 | 1.11 | 0.88 |
| Transcription factors | |||||
| STAT4 | L78440 | 5.93E+08 | 1.56E+08 | 3.81 | <0.001 |
| CAF1-like factor (CNOT3) | AF053318 | 1.23E+05 | 3.49E+04 | 3.52 | 0.009 |
| STAT1b | M97936 | 2.32E+09 | 5.77E+08 | 4.02 | 0.02 |
| Ca2+-modulating cyclophilin ligand (CAML) | NM_001745.1 | 1.24E+10 | 8.26E+09 | 1.50 | 0.03 |
| STAT6 | U16031 | 1.48E+09 | 4.71E+08 | 3.15 | 0.047 |
| IFN-stimulated transcription factor (STAT2) | M97934.1 | 2.83E+09 | 1.20E+09 | 2.37 | 0.1 |
| IL-1 receptor associated kinase (IRAK) | L76191.1 | 1.43E+09 | 5.03E+08 | 2.84 | 0.11 |
| TATA box binding protein-associated factor (TAFIID) | U18062 | 6.54E+09 | 3.28E+09 | 2.00 | 0.15 |
| Nuclear factor kappa b (NFKB) | M62399.1 | 2.40E+10 | 3.05E+10 | 0.79 | 0.17 |
| Transcription factor 1 (TCF1) | NM_003202.1 | 1.08E+07 | 2.93E+06 | 3.67 | 0.24 |
| STAT1a | M97935 | 6.89E+09 | 3.64E+09 | 1.89 | 0.35 |
| Hypoxia-inducible factor 1 (HIF1a) | U22431.1 | 5.59E+08 | 1.13E+09 | 0.49 | 0.43 |
| NFKB inhibitor (IKB) | AF031416.1 | 1.24E+10 | 1.49E+10 | 0.83 | 0.49 |
| STAT5 | L41142 | 1.02E+10 | 1.23E+10 | 0.83 | 0.49 |
| Early growth response 1 (EGR1) | NM_001964 | 3.54E+09 | 3.18E+09 | 1.11 | 0.84 |
| Chemokines | |||||
| SCYB14 (Brak) | NM_004887 | 4.02E+07 | 1.18E+07 | 3.98 | 0.002 |
| SCYA5 (RANTES) | AF043341 | 9.80E+09 | 1.77E+10 | 0.55 | 0.03 |
| SCYA21 (Exodus2/SLC) | AB002409 | 3.59E+09 | 1.55E+09 | 2.32 | 0.045 |
| SCYA19 (Exodus3) | NM_006274 | 6.13E+09 | 2.53E+09 | 2.42 | 0.052 |
| SCYA20 (MIP3A) | NM_004591 | 4.58E+06 | 8.74E+05 | 5.24 | 0.22 |
| Stromal cell-derived factor (SDF1b) | U16752 | 1.81E+09 | 3.94E+09 | 0.46 | 0.23 |
| SCYB5 (ENA78) | X78686.1 | 7.48E+06 | 1.59E+07 | 0.47 | 0.42 |
| Proteinases | |||||
| Cathepsin G (CTSG) | NM_001911 | 1.35E+09 | 1.29E+08 | 10.52 | 0.002 |
| Chymase (CMA1) | M69136.1 | 6.12E+08 | 2.25E+08 | 2.72 | 0.02 |
| Cathepsin C (CTSC) | NM_001814 | 4.23E+10 | 2.09E+10 | 2.02 | 0.07 |
| Granzyme A (GZMA) | M18737.1 | 1.57E+08 | 5.49E+07 | 2.86 | 0.39 |
| Beta-Tryptase (TPSB1) | NM_003294 | 6.66E+10 | 5.53E+10 | 1.20 | 0.41 |
| Cathepsin B (CTSB) | NM_001908 | 1.52E+10 | 1.25E+10 | 1.22 | 0.69 |
| Collagenase A (COL1A1) | J03210 | 7.50E+09 | 8.17E+09 | 0.92 | 0.83 |
| Channels and transporters | |||||
| Bumetanide-sensitive Na-K-Cl cotransporter (NKCC1) (SLC12A2) | U30246 | 3.77E+07 | 4.92E+06 | 7.66 | 0.01 |
| Organic cation transporter 1 (OCTN1) | U77086.1 | 9.70E+04 | 2.21E+04 | 4.39 | 0.04 |
| Large conductance calcium- and voltage dependent potassium channel (MAXIKP1) | U25138 | 3.72E+08 | 1.92E+08 | 1.94 | 0.1 |
| Organic cation transporter 2 (OCTN2) | AF057164 | 1.12E+07 | 9.07E+06 | 1.24 | 0.57 |
| Other genes | |||||
| Beta-Defensin 1 (DEFB1) | M26602 | 3.62E+09 | 8.41E+08 | 4.31 | 0.03 |
| CD80 ligand (IGB7) | M27533.1 | 6.73E+08 | 5.26E+08 | 1.28 | 0.46 |
| b-Glucuronidase (GUSB) | AF092051 | 6.30E+06 | 4.34E+06 | 1.45 | 0.47 |
| Cyclooxygenase2 (COX2) | M90100 | 2.83E+08 | 1.53E+08 | 1.85 | 0.48 |
| Granulysin (GNLY) | XM_002560 | 9.08E+08 | 1.09E+09 | 0.83 | 0.61 |
| Cadherin 18 (CDH18) | NM_004934 | 4.61E+06 | 3.88E+06 | 1.19 | 0.79 |
| Keratoepithelin (BIGH3) | M77349.1 | 5.86E+07 | 6.21E+07 | 0.94 | 0.82 |
