Looking at Old Tools in New Ways: Using Knockouts as Congenics to Study QTLs

Table 1.

B6.129-KO Strains Currently Commercially Available from the Jackson Laboratory (2001)

Strain Chr Position
B6.129S7-Il1r1tm11mx 1 19.1
B6.129S2-Cd28tm1Mak 1 30.1
B10.129P2(B6)-Il10tm1Cgn 1 69.9
B6.129S7-Selptm1Bay 1 86.6
B6.129S4-Cd3ztm1Lov 1 87.2
B6.129P2-Fcgr3tm1Sjv 1 92.3
B6.129P2-B2mtm1Unc 2 69
B6.129P2-Tnfrsf5tm1Kik 2 97
B6.129S1-Il12atm1Jm 3 37
B6.129-Tnfrsf1btm1Mwm 4 75.5
B6.129P2-Nos3tm1Unc 5 9
B6.129S6-Il6tm1Kopf 5 17
B6.129S7-Ldlrtm1Her 5 20
B6.129P2-Tcrbtm1Mom 6 20.5
B6.129S1-Il12rb2tm1Jm 6 30.1
B6.129S2-Cd8atm1Mak 6 30.5
B6.129S7-Gtrosa26 6 48.7
B6.129S7-Gtrosa26tmSho 6 48.7
B6.129S7-Gtrosa26tmSor 6 48.7
B6.129S2-Cd4tm1Mak 6 60.2
B6.129S6-Cd4tm1Knw 6 60.2
B6.129-Tnfrsf1atm1Mak 6 60.5
B6.129S4-Nft3tm2Jae 6 61
B6.129-Cdkn1btm1Mlf 6 62
B6.129P2-Apoetm1Unc 7 4
B6.129S7-Chrna7tm1Bay 7 30
B6.129S2-Plattml 8 9
B6.129S7-LdlrtmlHer 9 5
B6.129S4-Icam1tm1Jcgr 9 7
B6.129S7-Icamltm1Bay 9 7
B6.129P2-Apoa1tm1Unc 9 27
B6.129P2-Lipctm1Unc 9 39
B6.129S1-Grik2tm1Sfh 10 27
B6.129S7-Itgb2tm1Bay 10 41.5
B6.129S7-Ifngtm1Ts 10 67
B6.129-Il12btm1Jm 11 19
B6.129-Il2rgtm1Wjl 11 29
B6.129P2-Il4tm1Cgn 11 29
B6.129S2-Alox15tm1Fun 11 40
B6.129P2-Lipctm1Unc 11 45.6
B6.129P2-Scya3tm1Unc 11 47.6
B6.129S4-Ngfrtm1Jae 11 55.6
B6.129P2-Apobtm1Unc 12 2
B6.129-Ahrtm1Bra 12 18
B6.129S2-Igh-6tm1Cgn 12 58
B6.129P2-Agtr1atm1Unc 13 16
B6.129P2-Tcrdtm1Mom 14 19.5
B6.129S2-Tcratm1Mom 14 19.5
B6.129S7-I17rtm1Imx 15 4.6
B6.129S4-Cd86tm1Shr 16 26.9
B6.129S4-Cd80tm1Shr 16 28
B6.129P2-Plgtm1 17 7.3
B6.129S2-Ltatm1Dch 17 19.1
B6.129S4-C3tm1Crr 17 34.3
B6.129S-Cd14tm1Frm 18 31
B6.129S6-Iltm1Liz 18 32
B6.129S2-Tnfsf5tm11mx X 18
B6.129P2-Fmr1tm1Cgr X 24.5
B6.129-Il2rgtm1Wjl X 38
  • This list excludes knockouts that are cryopreserved, difficult to breed, severely immunodeficient, or homozygous lethal. There may be additional issues related to using some of these strains. In addition to the 59 strains listed, the Jackson Laboratory has 41 knockout strains in the process of being backcrossed to B6 and 74 strains which only exist as cryopreserved stocks. Many of the congenics are clustered and represent different knockouts of the same gene or different genes in gene clusters. These overlapping congenics were included because they will have considerable utility for fine mapping QTLs in the region.

This Article

  1. Genome Res. 11: 1469-1471

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