Looking at Old Tools in New Ways: Using Knockouts as Congenics to Study QTLs

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 1.
Figure 1.

Genome coverage using B6.129-KO strains available from The Jackson Laboratory. Coverage of the genome is shown assuming 20cM introgressed segments (the average segment size for an N10 backcross). Actual segment size will differ considerably from 20cM; thus, lack of coverage in the diagram does not necessarily imply the absence of an introgressed segment. Heavier shading reflects the likely presence of multiple segments at that location due to the existence of multiple strains.

This Article

  1. Genome Res. 11: 1469-1471

Preprint Server