Analysis of Conserved Noncoding DNA in Drosophila Reveals Similar Constraints in Intergenic and Intronic Sequences

Table 3.

Nucleotide Match–Mismatch Table for Conserved Noncoding Blocks betweenDrosophila melanogaster andDrosophila virilis

Drosophila melanogaster Drosophila virilis
A C G T
A  Intergenic 5501 (0.268) 86 (0.004) 150 (0.007) 82 (0.004)
 Intronic 2738 (0.291) 39 (0.004) 68 (0.007) 31 (0.003)
 Total 8239 (0.275) 125 (0.004) 218 (0.007) 113 (0.004)
C  Intergenic 108 (0.005) 3803 (0.186) 92 (0.004) 241 (0.012)
 Intronic 55 (0.006) 1676 (0.178) 45 (0.005) 72 (0.008)
 Total 163 (0.005) 5479 (0.183) 137 (0.005) 313 (0.010)
G  Intergenic 212 (0.010) 107 (0.005) 3937 (0.192) 78 (0.004)
 Intronic 97 (0.010) 36 (0.004) 1613 (0.171) 51 (0.005)
 Total 309 (0.010) 143 (0.005) 5550 (0.186) 129 (0.004)
T  Intergenic 96 (0.005) 150 (0.007) 101 (0.005) 5755 (0.281)
 Intronic 60 (0.006) 71 (0.008) 29 (0.003) 2733 (0.290)
 Total 156 (0.005) 221 (0.007) 130 (0.004) 8488 (0.284)
  • Each cell represents the observed numbers of matched and mismatched bases for nucleotide positions aligned in intergenic, intronic, and total conserved blocks. Rounded frequencies of observations are in parentheses and are scaled relative to intergenic (20,499), intronic (9,414), or grand (29,913) totals, which do not include ambiguous nucleotides.

  • Significant differences between reciprocal substitutions atP < 0.05/18 = 0.00278.

This Article

  1. Genome Res. 11: 1335-1345

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