Table 4.
Conserved LGR Hinge Sequences
| LGR4–6 consensus | YAYQCC | GXFKPCEX |
| rk | YAYHCC | GPFLPCAD |
| LGR4 | YAYQCC | GAFKPCEY |
| LGR5 | YAYQCC | GPFKPCEH |
| FEX | SAYQCC | GPFKPCEH |
| FSHR/LSHR/TSHR consensus | YPSHCC | DXFNPCED |
| Fsh | HSFHCC | NDLNPCED |
| NLGR | YPHHCC | DALNPCEN |
| FSHR_human | YPSHCC | DAFNPCED |
| LSHR_human | YPSHCC | DAFNPCED |
| TSHR_human | YPSHCC | DEFNPCED |
| ALGR | NGFLCC | DAFHPCED |
| LGR7 consensus | XZXZCX | DGZSSXXX |
| CG4187 | NVRVCD | DGISSKLH |
| CG5042 | RFFYCS | DGVSSFQD |
| LGR7 | KFQYCG | DGISSLEN |
| SLGR | SYRFCC | DEFSSCED |
| LDL receptor motif | ||
| CG4187 | NCDGSVDCDDASDEVNC | |
| CG5042 | CVPRRQMCDSRNDCADSSDENPVEC | |
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The consensus hinge sequences for LGR4–6 and FSHR/LSHR/TSHR were described by Hsu et al. (2000). The consensus hinge sequences for LGR7 are based on a ClustalX alignment of these four proteins.
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↵This sequence is truncated N-terminally, presumably due to missing sequence at the N-terminal end of the annotation.
