Tandem repeats in the Xist gene. (a) Schematic representation of tandem repeats in human, mouse, and voleXist gene. Similar repeats in different species are connected by thin lines. The size and features of specific repeats are indicated in e. (b) Schematic representation of the D repeat region. Individual copies and their position are indicated. Previously published region indicated as D core. Human D-core consists of 7.7 tandem copies, and mouse and vole contain five truncated copies of various length. Truncated copies of D repeat are found in surrounding regions in all three species, thereby increasing the length of D-repeat region. (c) Length and position of D repeat copies found in extended D region. The homology to previously published consensus is color coded. (d) alignment of F repeat region between M. kirgisorum (K), M. arvalis (A), M. rossiaemeridionalis (R), M. transcaspicus (T), mouse (M), and human (H). Consensus sequence containing a putative binding site is boxed. Positions of identical nucleotides in all six species are marked with asterisks. (e) Monomer size and copy number of tandem repeats in the Xist gene. 1M1 +M2 – motifs 1 and 2; numbers in brackets represent the monomer copy number in each species.
