First Pass Annotation of Promoters on Human Chromosome 22

Table 5.

Correlation of CpG Islands Filtered by Promoter Prediction tools NNPP 2.1 and Promoter 2.0 with Gene Annotation on Human Chromosome 22

Gene group # NNPP–CpG 462 (100%) Promoter 2.0–CpG 164 (100%)
abs. rel. O abs. rel. O
All genes 545 177 38.3% 6.8 84 51.2% 7.1
Known genes 247 120 25.9% 10.3 55 33.5% 12.4
Related genes 150 33 7.1% 4.8 11 6.7% 4.2
Predicted genes 148 49 10.6% 3.6 21 12.8% 4.2
Pseudo genes 134 9 1.9% 1.6 5 3.0% 2.5
Additional predictions 276 59.7% 75 45.7%
  • (#) Number of annotated genes.

  • (abs) Absolute number of predicted promoter regions that were found near annotated genes.

  • (rel) Percentage of predicted promoter regions that were found near annotated genes.

  • (O) X-fold overrepresentation, i.e., number of predicted promoter predictions that were found near annotated genes divided by the number that would be expected to be located near these genes if the same number of positions were distributed randomly across the chromosome.

  • Due to a small number of double scoring regions (a region is scored twice if it is supported by genes from different gene groups), the total number of annotation supported regions is not equal to the sum over the number of gene group-related annotation-supported promoter regions.

This Article

  1. Genome Res. 11: 333-340

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