First Pass Annotation of Promoters on Human Chromosome 22

Table 3.

Correlation of Predicted Promoter Regions and CpG Islands with Gene Annotation on Human Chromosome 22

Gene group # CpG island 543 (100%) PromoterInspector 465 (100%)
abs. rel. O abs. rel. O
All genes 545 214 39.4% 5.8 180 38.7% 6.3
Known genes 247 126 23.2% 9.3 111 23.9% 11.1
Related genes 150 39 7.2% 4.9 28 6.0% 4.6
Predicted genes 148 55 10.1% 3.4 47 10.1% 3.6
Pseudo genes 134 9 1.7% 1.4 6 1.3% 1.2
Additional predictions 320 58.9% 279 60.0%
  • (#) Number of annotated genes.

  • (abs) Absolute number of predicted promoter regions that were found near annotated genes.

  • (rel) Percentage of predicted promoter regions that were found near annotated genes.

  • (O) X-fold overrepresentation, i.e., number of predicted promoter predictions that were found near annotated genes divided by the number that would be expected to be located near these genes if the same number of posiitons were distributed randomly across the chromosome.

  • Due to a small number of double scoring regions (a region is scored twice if it is supported by genes from different gene groups), the total number of annotation supported regions is not equal to the sum over the number of gene group-related annotation-supported promoter regions.

This Article

  1. Genome Res. 11: 333-340

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