Table 1.

Mouse Genetic Models of Infectious Disease Susceptibility

	Disease	Position/Gene	References
Genetic variants in	Chagas Disease	N.D.	Trischmann 1984
susceptibility	Tularemia	N.D.	Anthony et al. 1988
Documented genetic	Anthrax	Chr. 11	Roberts et al. 1998
linkages	Mouse Cytomegalovirus	Chr. 6	Scalzo et al. 1990
	Leishmaniasis	Multiple QTL	Beebe et al. 1997; Roberts et al. 1997, 1999; Lipoldova et al. 2000
	Listeriosis	Multiple QTL	Boyartchuk et al. (in press)
	Malaria	Multiple QTL	Wunderlich et al. 1988; Foote et al. 1997; Fortin et al. 1997; Burt et al. 1999
	Salmonellosis	Multiple QTL	Sebastiani et al. 1998
	Sleeping Sickness	Multiple QTL	Kemp et al. 1997
Genes identified	Typhus	Etal	Patarca et al. 1989
	Gram Negative Septic Shock	Tlr4	Poltorak et al. 1998; Qureshi et al. 1999
	Influenza	Mx1	Staeheli et al. 1986

↵The chromosomal map position or gene name is provided, if known. (N.D.) Not determined.
↵ Slc11al alleles have an effect on mouse susceptibility to visceral Leishmaniasis pathogens, and toSalmonella typhimurium.
↵In addition to the genetic linkages cited here, other work has demonstrated that an additional locus for susceptibility toListeria resides on chromosome 2, and it has been suggested that polymorphisms in the C5 complement gene account for differences in susceptibility (Gervais et al. 1984).
↵Mouse malaria is caused by Plasmodium chabaudiinfection. Although P. chabaudi is not a human pathogen, it has many features of pathogenesis that resemble human malarias (Taylor-Robinson 1995).
↵Susceptibility to scrub typhus has been mapped to chromosome 5, and it has been suggested that polymorphisms in the Etalgene account for differences in susceptibility.

Using Mouse Genetics to Understand Infectious Disease Pathogenesis