Multiple sequence alignment of tandem duplication of CAP-related protein (CARP) domains in adenylyl cyclase-associated proteins (CAPs) and other proteins presented using CHROMA(Goodstadt and Ponting 2001). The tandem contiguous CARP domain repeats are shown in two successive tiers in the following order (amino acid numbers and GeneInfo codes): Homo sapiens (Hs) CAP1 (356–431: 399184); Saccharomyces cerevisiae (Sc) CAP (Srv2p) (406–481: 134897); Dictyostelium discoideum (Dd) CAP (344–419: 1705592); Schizosaccharomyces pombe (Sp) CAP (432–507: 543928); H. sapiens Xrp2 (67–140: 6831708); H. TCC (211–284; 6831693); H. sapiens FLJ10560 (337–410: 8922517);Arabidopsis thaliana (At) T5J17.90 (206–279: 7487709),Schizosaccharomyces pombe SPAC328.08c (151–223: 8894859); andS. cerevisiae Cin2p (130–208: 1168956). Underlined residues in human RP2 are mutated in individuals with X-linked retinitis pigmentosa (Schwahn et al. 1998; Mears et al. 1999). Secondary structures predicted (Rost and Sander 1993) at expected accuracies of >82% (E) or >72% (e) are indicated below the alignment (E/e, extended or β-strand structure).
