Conservation, Regulation, Synteny, and Introns in a Large-scale C. briggsae–C. elegans Genomic Alignment

Table 8.

Profiles of Nucleotide Frequencies Adjacent to 5′ and 3′ Splice Sites

Base frequency profile near 5′ splice site
A a 32% 30% 33% 20% 32% 82% 4% ^ 0.0% 0.0% 62% 51% 8% 23% 24%
c 33% 17% 11% 40% 32% 5% 4% ^ 0.0% 0.0% 0.0% 6% 14% 24% 12%
g 11% 14% 17% 18% 24% 1% 88% ^ 100% 0.0% 20% 18% 66% 4% 5%
t 24% 39% 39% 22% 12% 12% 3% ^ 0.0% 100% 17% 25% 13% 49% 59%
B a 28% 29% 30% 34% 38% 63% 13% ^ 0.0% 0.0% 62% 60% 12% 25% 29%
c 24% 15% 17% 20% 20% 9% 5% ^ 0.0% 0.0% 0.0% 4% 5% 8% 14%
g 18% 28% 18% 13% 21% 10% 76% ^ 100% 0.0% 15% 15% 63% 7% 9%
t 29% 27% 34% 33% 21% 17% 6% ^ 0.0% 100% 23% 21% 19% 60% 48%
C a 28% 30% 35% 36% 40% 56% 18% ^ 0.0% 0.0% 58% 66% 10% 19% 26%
c 18% 18% 17% 18% 23% 14% 7% ^ 0.0% 0.0% 2% 8% 3% 10% 10%
g 23% 23% 17% 17% 20% 11% 60% ^ 100% 0.0% 24% 9% 75% 9% 13%
t 32% 28% 31% 28% 17% 18% 14% ^ 0.0% 100% 16% 17% 11% 62% 51%
Base frequency profile near 3′ splice site
D a 19% 4% 1% 28% 0.0% 100% 0.0% ^ 23% 30% 44% 22% 25% 17% 30%
c 19% 5% 2% 12% 84% 0.0% 0.0% ^ 25% 23% 24% 11% 44% 49% 20%
g 9% 2% 0.0% 9% 0.0% 0.0% 100% ^ 49% 11% 10% 18% 8% 4% 16%
t 53% 88% 97% 52% 16% 0.0% 0.0% ^ 3% 37% 23% 49% 24% 29% 33%
E a 34% 7% 0.5% 11% 2% 100% 0.0% ^ 29% 27% 38% 30% 31% 23% 36%
c 7% 2% 0.5% 11% 80% 0.0% 0.0% ^ 14% 20% 21% 24% 27% 32% 20%
g 5% 4% 0.0% 8% 0.0% 0.0% 100% ^ 46% 12% 16% 23% 17% 17% 23%
t 55% 88% 99% 70% 18% 0.0% 0.0% ^ 12% 41% 24% 23% 25% 28% 21%
F a 28% 5% 1% 9% 3% 100% 0.0% ^ 41% 30% 30% 28% 30% 28% 29%
c 8% 3% 1% 16% 84% 0.0% 0.0% ^ 16% 19% 23% 26% 26% 29% 26%
g 6% 2% 0.3% 8% 0.1% 0.0% 100% ^ 31% 16% 19% 22% 18% 19% 23%
t 58% 90% 97% 67% 13% 0.0% 0.0% ^ 13% 36% 28% 25% 26% 24% 22%
  • Profiles for the 93 introns unique to C. briggsae(A,D), the 170 introns unique to C. elegans (B,E), and the 28085 C. elegans introns that have canonical GT … AG ends (C,F). The caret (^) indicates the splice site. Note that the consensus of AG immediately before the 3′ splice site is much stronger for unique introns, particularly introns unique to C. briggsae, than it is for C. elegans introns as a whole.

This Article

  1. Genome Res. 10: 1115-1125

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