Conservation, Regulation, Synteny, and Introns in a Large-scale C. briggsae–C. elegans Genomic Alignment

Table 1.

Comparison of BLASTN and WABA Alignments

BLASTN default BLASTN −W8−f8 WABA
Total base matches 1849727 1969827 4697347
Total base mismatches 314023 340606 2538033
Total bases inserted 5859 5659 2275269
Total number of inserts 2836 2962 27469
Number of alignments 14653 16247 3839
Average size of alignments 147.9 142.4 2059.3
C. briggsaecosmids total 229 229 229
Cosmids with any alignment 224 224 227
Seconds to align one cosmid 60 2461 1420
  • Only alignments containing 50 or more base matches are included here. BLASTN was run at the default settings and with the window size and the minimum extension score set down to eight for increased sensitivity. WABA is more tolerant of long inserts and nucleotide mismatches than BLASTN at either setting and consequently is able to make longer alignments.

This Article

  1. Genome Res. 10: 1115-1125

Preprint Server