Volume 10, Issue 4 | April 2000

INSIGHT/OUTLOOK
- - A Biologist's View of the Drosophila Genome Annotation Assessment Project
    Michael Ashburner
    First Published April 1, 2000
  - Gene-Finding Approaches for Eukaryotes
    Gary D. Stormo
    First Published April 1, 2000
  - Powers and Pitfalls in Sequence Analysis: The 70% Hurdle
    Peer Bork
    First Published April 1, 2000
REVIEW
- - Evolution and Variation of the Yeast (Saccharomyces) Genome
    Robert K. Mortimer
    First Published April 1, 2000
REPORT
- - Frequent Human Genomic DNA Transduction Driven by LINE-1 Retrotransposition
    Oxana K. Pickeral
    Wojciech Makałowski
    Mark S. Boguski
    Jef D. Boeke
    First Published April 1, 2000
ARTICLES
- - Large-Scale Comparison of Fungal Sequence Information: Mechanisms of Innovation in Neurospora crassa and Gene Loss in Saccharomyces cerevisiae
    Edward L. Braun
    Aaron L. Halpern
    Mary Anne Nelson
    Donald O. Natvig
    First Published April 1, 2000
  - Systematic Management and Analysis of Yeast Gene Expression Data
    John Aach
    Wayne Rindone
    George M. Church
    First Published April 1, 2000
LETTERS
- - Congenic Mapping of the Type 1 Diabetes Locus, Idd3, to a 780-kb Region of Mouse Chromosome 3: Identification of a Candidate Segment of Ancestral DNA by Haplotype Mapping
    Paul A. Lyons
    Nicola Armitage
    Fabio Argentina
    Paul Denny
    Natasha J. Hill
    Christopher J. Lord
    ...[+1 authors]...,
    Mary Beth Wilusz
    Laurence B. Peterson
    Linda S. Wicker
    John A. Todd
    First Published April 1, 2000
  - Construction of a High-Resolution 2.5-Mb Transcript Map of the Human 6p21.2–6p21.3 Region Immediately Centromeric of the Major Histocompatibility Complex
    Nicos Tripodis
    Sophie Palmer
    Sam Phillips
    Sarah Milne
    Stephan Beck
    First Published April 1, 2000
  - New Target Regions for Human Hypertension via Comparative Genomics
    Monika Stoll
    Anne E. Kwitek-Black
    Allen W. Cowley
    Eugenie L. Harris
    Stephen B. Harrap
    José E. Krieger
    ...[+1 authors]...,
    Morton P. Printz
    Abraham P. Provoost
    Jean Sassard
    Howard J. Jacob
    First Published April 1, 2000
  - Genome Annotation Assessment in Drosophila melanogaster
    Martin G. Reese
    George Hartzell
    Nomi L. Harris
    Uwe Ohler
    Josep F. Abril
    First Published April 1, 2000
METHODS
- - MAGPIE/EGRET Annotation of the 2.9-Mb Drosophila melanogaster Adh Region
    Terry Gaasterland
    Alexander Sczyrba
    Elizabeth Thomas
    Gulriz Aytekin-Kurban
    Paul Gordon
    First Published April 1, 2000
  - GeneID in Drosophila
    Genís Parra
    Enrique Blanco
    Roderic Guigó
    First Published April 1, 2000
  - Ab initio Gene Finding in Drosophila Genomic DNA
    Asaf A. Salamov
    Victor V. Solovyev
    First Published April 1, 2000
  - Using Database Matches with HMMGene for Automated Gene Detection in Drosophila
    Anders Krogh
    First Published April 1, 2000
  - Genie—Gene Finding in Drosophila melanogaster
    Martin G. Reese
    David Kulp
    Hari Tammana
    David Haussler
    First Published April 1, 2000
  - Promoter Prediction on a Genomic Scale—The Adh Experience
    Uwe Ohler
    First Published April 1, 2000
  - Drosophila Genomic Sequence Annotation Using the BLOCKS+ Database
    Jorja G. Henikoff
    Steven Henikoff
    First Published April 1, 2000
  - Using GeneWise in the Drosophila Annotation Experiment
    Ewan Birney
    Richard Durbin
    First Published April 1, 2000
  - A Microsphere-Based Assay for Multiplexed Single Nucleotide Polymorphism Analysis Using Single Base Chain Extension
    Jingwen Chen
    Marie A. Iannone
    May-Sung Li
    J. David Taylor
    Philip Rivers
    First Published April 1, 2000
RESOURCES
- - Genetic Linkage Mapping of Zebrafish Genes and ESTs
    Peter D. Kelly
    Felicia Chu
    Ian G. Woods
    Phuong Ngo-Hazelett
    Timothy Cardozo
    Hui Huang Frankie Kimm Lingya Liao Yi-Lin Yan Yingyao Zhou Steven L. Johnson
    ...[+6 authors]...,
    Ruben Abagyan
    Alexander F. Schier
    John H. Postlethwait
    William S. Talbot
    First Published April 1, 2000
  - Global Properties of the Metabolic Map of Escherichia coli
    Christos A. Ouzounis
    Peter D. Karp
    First Published April 1, 2000
  - PipMaker—A Web Server for Aligning Two Genomic DNA Sequences
    Scott Schwartz
    Zheng Zhang
    Kelly A. Frazer
    Arian Smit
    Cathy Riemer
    First Published April 1, 2000

Table of Contents

Volume 10, Issue 4 | April 2000

INSIGHT/OUTLOOK

A Biologist's View of the Drosophila Genome Annotation Assessment Project

Gene-Finding Approaches for Eukaryotes

Powers and Pitfalls in Sequence Analysis: The 70% Hurdle

REVIEW

Evolution and Variation of the Yeast (Saccharomyces) Genome

REPORT

Frequent Human Genomic DNA Transduction Driven by LINE-1 Retrotransposition

ARTICLES

Large-Scale Comparison of Fungal Sequence Information: Mechanisms of Innovation in Neurospora crassa and Gene Loss in Saccharomyces cerevisiae

Systematic Management and Analysis of Yeast Gene Expression Data

LETTERS

Congenic Mapping of the Type 1 Diabetes Locus, Idd3, to a 780-kb Region of Mouse Chromosome 3: Identification of a Candidate Segment of Ancestral DNA by Haplotype Mapping

Construction of a High-Resolution 2.5-Mb Transcript Map of the Human 6p21.2–6p21.3 Region Immediately Centromeric of the Major Histocompatibility Complex

New Target Regions for Human Hypertension via Comparative Genomics

Genome Annotation Assessment in Drosophila melanogaster

METHODS

MAGPIE/EGRET Annotation of the 2.9-Mb Drosophila melanogaster Adh Region

GeneID in Drosophila

Ab initio Gene Finding in Drosophila Genomic DNA

Using Database Matches with HMMGene for Automated Gene Detection in Drosophila

Genie—Gene Finding in Drosophila melanogaster

Promoter Prediction on a Genomic Scale—The Adh Experience

Drosophila Genomic Sequence Annotation Using the BLOCKS+ Database

Using GeneWise in the Drosophila Annotation Experiment

A Microsphere-Based Assay for Multiplexed Single Nucleotide Polymorphism Analysis Using Single Base Chain Extension

RESOURCES

Genetic Linkage Mapping of Zebrafish Genes and ESTs

Global Properties of the Metabolic Map of Escherichia coli

PipMaker—A Web Server for Aligning Two Genomic DNA Sequences

Table of Contents

Volume 10, Issue 4 | April 2000

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INSIGHT/OUTLOOK

REVIEW

REPORT

ARTICLES

LETTERS

METHODS

RESOURCES