Figure 1.
Physical map of the 204 kb flanking the Clock locus. TheClock locus lies at the midportion of mouse chromosome 5. The genomic locus is updated from Antoch et al. (1997); genetic markers and restriction sites are indicated on the chromosomal and YAC55 maps. The positions of pseudogenes Pafah1b1-ps2 (2 copies),bendless, and APC are shown relative to Nmu,Pdcl2, Clock, Tpardl, and Srd5a2l. The bacterial artificial chromosome (BAC) clones that rescue theClock mutation, BAC54 and BAC49, are shaded, whereas the nonrescuing BAC clones 52 and 54 (100 kb) are shown as open boxes. BAC 54 and BAC 52 were sequenced to generate the data presented here.
