Table 6.
Results of the UniGene/EST Screen
| Description | UniGene ID | Endothelial hits |
| TIE1 receptor endothelial tyrosine kinase | Hs.78824 | 5 |
| Cytosolic phospholipase A2; involved in the metabolism of eicosanoids | Hs.211587 | 3 |
| Branched chain alpha-ketoacid dehydrogenase | Hs.1265 | 2 |
| CGMP-dependent protein kinase; cloned from aorta cDNA, strongly expressed in well vascularised tissues like aorta, heart, and uterus (Tamura et al. 1996) | Hs.2689 | 2 |
| Lymphatic vessel endothelial hyaluronan receptor 1-LYVE1 (Banerji et al. 1999) | Hs.17917 | 2 |
| TRAF interacting protein: TNF signalling pathway | Hs.21254 | 2 |
| Multimerin: a very big endothelial-specific protein; binds platelet factor V, can also be found in platelets (Hayward et al. 1996) | Hs.32934 | 2 |
| Diubiquitin (a member of the ubiquitin family); reported in dendrytic and B lymphocyte cells; involved in antigen processing; this is first evidence that it is also present in endothelial cells (Bates et al. 1997) | Hs.44532 | 2 |
| Beta-transducin family protein; also a homolog of D. melanogaster gene notchless: a novel WD40 repeat containing protein that modulates Notch signalling activity | Hs.85570 | 2 |
| TIE2/TEK receptor endothelial tyrosine kinase | Hs.89640 | 2 |
| BCL2 associated X protein (BAX) | Hs.159428 | 2 |
| Sepiapterin reductase mRNA | Hs.160100 | 2 |
| Retinoic acid receptor beta (RARB) | Hs.171495 | 2 |
| ST2 receptor: a homolog of the interleukin 1 receptor | Hs.66 | 1 |
| Mitogen activated protein kinase 8 (MAPK8) | Hs.859 | 1 |
| ERG gene related to the ETS oncogene | Hs.45514 | 1 |
| PP35 similar to Escherichia coli yhdg and Rhodobacter capsulatusnifR3 | Hs.97627 | 1 |
| Interphotoreceptor matrix proteoglycan; strongly expressed in retina and umbilical cord vein (Felbor et al. 1998) | Hs.129882 | 1 |
| Methylmalonate semialdehyde dehydrogenase gene | Hs.170008 | 1 |
| HTLV-I–related endogenous retroviral sequence | Hs.247963 | 1 |
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Twenty known genes were selected in the UniGene/EST screen (no hits in the nonendothelial pool and at least one hit in the endothelial pool). At least four of these genes are known endothelial-specific genes: TIE1, TIE2/TEK, LVYE1, and multimerin, indicating ∼20% prediction accuracy. Other genes, although certainly preferentially expressed in the endothelial cells, may not be endothelial specific.
