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Research

Correlated alterations in genome organization, histone methylation, and DNA–lamin A/C interactions in Hutchinson-Gilford progeria syndrome

  • First Published November 14, 2012
Resource

Pyrus bretschneideri Rehd.)" > The genome of the pear (Pyrus bretschneideri Rehd.)

  • First Published November 13, 2012
Research

Functional genomic analysis of chromosomal aberrations in a compendium of 8000 cancer genomes

  • First Published November 6, 2012
Method

Genome-scale coestimation of species and gene trees

  • First Published November 6, 2012
Research

Targeted gene silencing in mouse germ cells by insertion of a homologous DNA into a piRNA generating locus

  • First Published November 6, 2012
Research

Constitutive nuclear lamina–genome interactions are highly conserved and associated with A/T-rich sequence

  • First Published November 2, 2012
Research

Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability

  • First Published November 2, 2012
Research

Stabilization of the promoter nucleosomes in nucleosome-free regions by the yeast Cyc8–Tup1 corepressor

  • First Published November 2, 2012
Research

Autozygome-guided exome sequencing in retinal dystrophy patients reveals pathogenetic mutations and novel candidate disease genes

  • First Published October 26, 2012
Research

CpG islands and GC content dictate nucleosome depletion in a transcription-independent manner at mammalian promoters

  • First Published October 25, 2012
Method

Modeling kinetic rate variation in third generation DNA sequencing data to detect putative modifications to DNA bases

  • First Published October 23, 2012
Research

Zea mays L.) hybrids relative to their inbred parents" > Complementation contributes to transcriptome complexity in maize (Zea mays L.) hybrids relative to their inbred parents

  • First Published October 19, 2012
Research

Pluripotent stem cells escape from senescence-associated DNA methylation changes

  • First Published October 18, 2012
Research

Comparative motif discovery combined with comparative transcriptomics yields accurate targetome and enhancer predictions

  • First Published October 15, 2012
Research

Differentially expressed, variant U1 snRNAs regulate gene expression in human cells

  • First Published October 15, 2012
Research

Nurture trumps nature in a longitudinal survey of salivary bacterial communities in twins from early adolescence to early adulthood

  • First Published October 12, 2012
Method

Sequencing the unsequenceable: Expanded CGG-repeat alleles of the fragile X gene

  • First Published October 11, 2012
Method

Genotype calling and haplotyping in parent-offspring trios

  • First Published October 11, 2012
Research

LRRC37 gene family" > Evolutionary dynamism of the primate LRRC37 gene family

  • First Published October 11, 2012
Method

Linking the signaling cascades and dynamic regulatory networks controlling stress responses

  • First Published October 11, 2012
Method

SeqFold: Genome-scale reconstruction of RNA secondary structure integrating high-throughput sequencing data

  • First Published October 11, 2012
Research

Drosophila mauritiana" > Genome-wide patterns of natural variation reveal strong selective sweeps and ongoing genomic conflict in Drosophila mauritiana

  • First Published October 10, 2012
Method

PUB-NChIP—“in vivo biotinylation” approach to study chromatin in proximity to a protein of interest

  • First Published October 4, 2012
Resource

A calibrated human Y-chromosomal phylogeny based on resequencing

  • First Published October 4, 2012
Research

Small noncoding differentially methylated copy-number variants, including lncRNA genes, cause a lethal lung developmental disorder

  • First Published October 3, 2012
Research

Birth and expression evolution of mammalian microRNA genes

  • First Published October 3, 2012
Research

Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events

  • First Published October 2, 2012
Method

Spatiotemporal clustering of the epigenome reveals rules of dynamic gene regulation

  • First Published October 2, 2012
Method

Haplotype-based profiling of subtle allelic imbalance with SNP arrays

  • First Published October 1, 2012
Erratum

Erratum

  • First Published October 1, 2012
Research

Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer

  • First Published October 1, 2012
Perspective

Translating genomic information into clinical medicine: Lung cancer as a paradigm

  • First Published September 27, 2012
Method

Integration of ChIP-seq and machine learning reveals enhancers and a predictive regulatory sequence vocabulary in melanocytes

  • First Published September 27, 2012
Research

Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner

  • First Published September 26, 2012
Method

Efficient targeted mutagenesis in the monarch butterfly using zinc-finger nucleases

  • First Published September 25, 2012
Method

P-value-based regulatory motif discovery using positional weight matrices" > P-value-based regulatory motif discovery using positional weight matrices

  • First Published September 18, 2012
Research

Computational analysis and characterization of UCE-like elements (ULEs) in plant genomes

  • First Published September 17, 2012
Research

The transcriptional landscape and mutational profile of lung adenocarcinoma

  • First Published September 13, 2012
Resource

SOAPindel: Efficient identification of indels from short paired reads

  • First Published September 12, 2012
Research

Extensive somatic L1 retrotransposition in colorectal tumors

  • First Published September 11, 2012
Research

Modeling of epigenome dynamics identifies transcription factors that mediate Polycomb targeting

  • First Published September 10, 2012
Method

Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules

  • First Published September 7, 2012
Research

Sex-biased genetic effects on gene regulation in humans

  • First Published September 7, 2012
Resource

Xenopus tropicalis transcriptome over development" > RNA sequencing reveals a diverse and dynamic repertoire of the Xenopus tropicalis transcriptome over development

  • First Published September 7, 2012
Method

Spark: A navigational paradigm for genomic data exploration

  • First Published September 7, 2012
Research

Natural genetic variation in yeast longevity

  • First Published September 5, 2012
Research

Dynamic landscape of tandem 3′ UTRs during zebrafish development

  • First Published September 5, 2012
Resource

Annotation of functional variation in personal genomes using RegulomeDB

  • First Published September 5, 2012
Perspective

Toward mapping the biology of the genome

  • First Published September 5, 2012
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