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Research

Inputs drive cell phenotype variability

  • First Published March 26, 2014
Research

Widespread context dependency of microRNA-mediated regulation

  • First Published March 25, 2014
Research

High-resolution mapping defines the cooperative architecture of Polycomb response elements

  • First Published March 25, 2014
Research

Identifying mRNA sequence elements for target recognition by human Argonaute proteins

  • First Published March 24, 2014
Research

C. elegans and humans" > Extreme HOT regions are CpG-dense promoters in C. elegans and humans

  • First Published March 20, 2014
Research

Meis1 alters enhancer function in the developing telencephalon" > Restless Legs Syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon

  • First Published March 18, 2014
Research

Cnidarian microRNAs frequently regulate targets by cleavage

  • First Published March 18, 2014
Research

Evolutionary conservation of the eumetazoan gene regulatory landscape

  • First Published March 18, 2014
Research

Genome-wide signals of positive selection in human evolution

  • First Published March 11, 2014
Research

C. elegans" > Polymerase theta-mediated end joining of replication-associated DNA breaks in C. elegans

  • First Published March 10, 2014
Method

Identifying genetic relatives without compromising privacy

  • First Published March 10, 2014
Research

PRDM9 binding organizes hotspot nucleosomes and limits Holliday junction migration

  • First Published March 6, 2014
Method

General approach for in vivo recovery of cell type-specific effector gene sets

  • First Published March 6, 2014
Research

Drosophila" > Tempo and mode of regulatory evolution in Drosophila

  • First Published February 24, 2014
Research

D. melanogaster is found at specific short motifs and is independent of DNMT2 activity" > Genome methylation in D. melanogaster is found at specific short motifs and is independent of DNMT2 activity

  • First Published February 20, 2014
Research

Widespread and frequent horizontal transfers of transposable elements in plants

  • First Published February 11, 2014
Research

Reprogramming of the human intestinal epigenome by surgical tissue transposition

  • First Published February 10, 2014
Research

Drosophila" > Evolution of splicing regulatory networks in Drosophila

  • First Published February 10, 2014
Method

ISMARA: automated modeling of genomic signals as a democracy of regulatory motifs

  • First Published February 10, 2014
Method

Statistical confidence estimation for Hi-C data reveals regulatory chromatin contacts

  • First Published February 5, 2014
Method

Centromere reference models for human chromosomes X and Y satellite arrays

  • First Published February 5, 2014
Research

Epigenetic modification and inheritance in sexual reversal of fish

  • First Published February 2, 2014
Research

A genomic portrait of the genetic architecture and regulatory impact of microRNA expression in response to infection

  • First Published January 30, 2014
Research

Enhancer-targeted genome editing selectively blocks innate resistance to oncokinase inhibition

  • First Published January 17, 2014
Research

Evolutionary dynamics and tissue specificity of human long noncoding RNAs in six mammals

  • First Published January 15, 2014
Method

Reconstructing complex regions of genomes using long-read sequencing technology

  • First Published January 13, 2014
Research

Age-related epigenetic drift in the pathogenesis of MDS and AML

  • First Published January 10, 2014
Resource

A biochemical landscape of A-to-I RNA editing in the human brain transcriptome

  • First Published January 9, 2014
Research

Drosophila melanogaster" > A long-term demasculinization of X-linked intergenic noncoding RNAs in Drosophila melanogaster

  • First Published January 9, 2014
Research

Arabidopsis" > Genome-wide identification of long noncoding natural antisense transcripts and their responses to light in Arabidopsis

  • First Published January 8, 2014
Research

H2A.B facilitates transcription elongation at methylated CpG loci

  • First Published January 8, 2014
Research

Genome-wide parent-of-origin DNA methylation analysis reveals the intricacies of human imprinting and suggests a germline methylation-independent mechanism of establishment

  • First Published January 8, 2014
Research

Functional and topological characteristics of mammalian regulatory domains

  • First Published January 7, 2014
Resource

An unbiased resource of novel SNP markers provides a new chronology for the human Y chromosome and reveals a deep phylogenetic structure in Africa

  • First Published January 6, 2014
Research

Genomic analysis of primordial dwarfism reveals novel disease genes

  • First Published January 3, 2014
Resource

Simultaneous identification and prioritization of variants in familial, de novo, and somatic genetic disorders with VariantMaster

  • First Published January 3, 2014
Research

Transcriptome analysis reveals novel players in the cranial neural crest gene regulatory network

  • First Published January 3, 2014
Method

A novel method for detecting uniparental disomy from trio genotypes identifies a significant excess in children with developmental disorders

  • First Published December 19, 2013
Research

A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes

  • First Published December 17, 2013
Research

Principles of nucleation of H3K27 methylation during embryonic development

  • First Published December 11, 2013
Research

An integrated systems genetics screen reveals the transcriptional structure of inherited predisposition to metastatic disease

  • First Published December 9, 2013
Research

Evolution at two levels of gene expression in yeast

  • First Published December 6, 2013
Research

Ribosome profiling reveals post-transcriptional buffering of divergent gene expression in yeast

  • First Published December 6, 2013
Method

Most parsimonious reconciliation in the presence of gene duplication, loss, and deep coalescence using labeled coalescent trees

  • First Published December 5, 2013
Research

The spring-loaded genome: Nucleosome redistributions are widespread, transient, and DNA-directed

  • First Published December 5, 2013
Research

cis-mediated silencing in somatic cells" > Systematic mapping of occluded genes by cell fusion reveals prevalence and stability of cis-mediated silencing in somatic cells

  • First Published December 5, 2013
Resource

Endothelial, epithelial, and fibroblast cells exhibit specific splicing programs independently of their tissue of origin

  • First Published December 4, 2013
Research

Regulatory modules controlling maize inflorescence architecture

  • First Published December 4, 2013
Method

TIGRA: A targeted iterative graph routing assembler for breakpoint assembly

  • First Published December 4, 2013
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