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Research

Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells

  • First Published May 11, 2015
Research

Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo

  • First Published May 8, 2015
Research

The landscape of genomic imprinting across diverse adult human tissues

  • First Published May 7, 2015
Research

Unmasking alternative splicing inside protein-coding exons defines exitrons and their role in proteome plasticity

  • First Published May 1, 2015
Resource

Using populations of human and microbial genomes for organism detection in metagenomes

  • First Published April 29, 2015
Research

C. elegans" > Coordinated tissue-specific regulation of adjacent alternative 3′ splice sites in C. elegans

  • First Published April 28, 2015
Research

Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders

  • First Published April 27, 2015
Method

A pooling-based approach to mapping genetic variants associated with DNA methylation

  • First Published April 24, 2015
Method

Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity

  • First Published April 23, 2015
Research

The clustering of functionally related genes contributes to CNV-mediated disease

  • First Published April 17, 2015
Method

An efficient and scalable analysis framework for variant extraction and refinement from population-scale DNA sequence data

  • First Published April 16, 2015
Research

Widespread exon skipping triggers degradation by nuclear RNA surveillance in fission yeast

  • First Published April 16, 2015
Research

Characterization and dynamics of pericentromere-associated domains in mice

  • First Published April 16, 2015
Research

Antagonistic regulation of mRNA expression and splicing by CELF and MBNL proteins

  • First Published April 16, 2015
Research

Characteristics of de novo structural changes in the human genome

  • First Published April 16, 2015
Research

Germline and somatic imprinting in the nonhuman primate highlights species differences in oocyte methylation

  • First Published April 10, 2015
Research

C. albicans infection in various niches" > New signaling pathways govern the host response to C. albicans infection in various niches

  • First Published April 9, 2015
Method

Optimizing sparse sequencing of single cells for highly multiplex copy number profiling

  • First Published April 9, 2015
Erratum

Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles" > Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles

  • First Published April 1, 2015
Erratum

BRF1 mutations alter RNA polymerase III–dependent transcription and cause neurodevelopmental anomalies" > BRF1 mutations alter RNA polymerase III–dependent transcription and cause neurodevelopmental anomalies

  • First Published April 1, 2015
Method

Accurate typing of short tandem repeats from genome-wide sequencing data and its applications

  • First Published March 30, 2015
Research

Arabidopsis and humans" > Organelle DNA rearrangement mapping reveals U-turn-like inversions as a major source of genomic instability in Arabidopsis and humans

  • First Published March 23, 2015
Research

Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes

  • First Published March 23, 2015
Research

Global variability in gene expression and alternative splicing is modulated by mitochondrial content

  • First Published March 23, 2015
Research

Evidence for widespread subfunctionalization of splice forms in vertebrate genomes

  • First Published March 19, 2015
Research

Extensive microRNA-mediated crosstalk between lncRNAs and mRNAs in mouse embryonic stem cells

  • First Published March 19, 2015
Research

Caenorhabditis" > Full-genome evolutionary histories of selfing, splitting, and selection in Caenorhabditis

  • First Published March 17, 2015
Research

A nucleosome turnover map reveals that the stability of histone H4 Lys20 methylation depends on histone recycling in transcribed chromatin

  • First Published March 16, 2015
Research

A recent bottleneck of Y chromosome diversity coincides with a global change in culture

  • First Published March 13, 2015
Method

Effect of minichromosome maintenance protein 2 deficiency on the locations of DNA replication origins

  • First Published March 11, 2015
Research

h chromosome" > Origin and domestication of papaya Yh chromosome

  • First Published March 11, 2015
Method

Unraveling determinants of transcription factor binding outside the core binding site

  • First Published March 11, 2015
Resource

The pluripotent regulatory circuitry connecting promoters to their long-range interacting elements

  • First Published March 9, 2015
Research

The role of DNA methylation in directing the functional organization of the cancer epigenome

  • First Published March 6, 2015
Research

ChIP-exo signal associated with DNA-binding motifs provides insight into the genomic binding of the glucocorticoid receptor and cooperating transcription factors

  • First Published February 26, 2015
Research

Dynamics of chromatin accessibility and long-range interactions in response to glucocorticoid pulsing

  • First Published February 12, 2015
Method

Joint annotation of chromatin state and chromatin conformation reveals relationships among domain types and identifies domains of cell-type-specific expression

  • First Published February 12, 2015
Research

Spatial enhancer clustering and regulation of enhancer-proximal genes by cohesin

  • First Published February 12, 2015
Method

Detection and phasing of single base de novo mutations in biopsies from human in vitro fertilized embryos by advanced whole-genome sequencing

  • First Published February 11, 2015
Research

Accurate, multi-kb reads resolve complex populations and detect rare microorganisms

  • First Published February 9, 2015
Method

MIPSTR: a method for multiplex genotyping of germline and somatic STR variation across many individuals

  • First Published February 6, 2015
Method

Bacterial genome reduction using the progressive clustering of deletions via yeast sexual cycling

  • First Published February 5, 2015
Research

The inactive X chromosome is epigenetically unstable and transcriptionally labile in breast cancer

  • First Published February 4, 2015
Research

DNA methylation at hepatitis B viral integrants is associated with methylation at flanking human genomic sequences

  • First Published February 4, 2015
Research

Methylomic trajectories across human fetal brain development

  • First Published February 3, 2015
Research

The spatial and temporal organization of origin firing during the S-phase of fission yeast

  • First Published February 3, 2015
Research

Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution

  • First Published February 3, 2015
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