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Research

Comprehensive benchmarking reveals H2BK20 acetylation as a distinctive signature of cell-state-specific enhancers and promoters

  • First Published March 8, 2016
Method

2C-Cas9: a versatile tool for clonal analysis of gene function

  • First Published March 8, 2016
Research

4 grass" > Drought responsive gene expression regulatory divergence between upland and lowland ecotypes of a perennial C4 grass

  • First Published March 7, 2016
Research

Sister chromatid telomere fusions, but not NHEJ-mediated inter-chromosomal telomere fusions, occur independently of DNA ligases 3 and 4

  • First Published March 3, 2016
Research

Human MAF1 targets and represses active RNA polymerase III genes by preventing recruitment rather than inducing long-term transcriptional arrest

  • First Published March 3, 2016
Method

A time- and cost-effective strategy to sequence mammalian Y Chromosomes: an application to the de novo assembly of gorilla Y

  • First Published March 2, 2016
Research

Genome-wide A-to-I RNA editing in fungi independent of ADAR enzymes

  • First Published March 2, 2016
Research

Callithrix jacchus genome" > Discovery of a new repeat family in the Callithrix jacchus genome

  • First Published February 25, 2016
Research

Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: support for a variable-size bottleneck

  • First Published February 25, 2016
Method

Integrative subcellular proteomic analysis allows accurate prediction of human disease-causing genes

  • First Published February 24, 2016
Research

Enhancer methylation dynamics contribute to cancer plasticity and patient mortality

  • First Published February 23, 2016
Research

PTCH1 as a major contributor to ocular developmental anomalies and extends the SOX2 regulatory network" > Targeted resequencing identifies PTCH1 as a major contributor to ocular developmental anomalies and extends the SOX2 regulatory network

  • First Published February 18, 2016
Research

Neurospora tetrasperma" > Introgression maintains the genetic integrity of the mating-type determining chromosome of the fungus Neurospora tetrasperma

  • First Published February 18, 2016
Research

Alternative splicing modulated by genetic variants demonstrates accelerated evolution regulated by highly conserved proteins

  • First Published February 17, 2016
Research

Whole-genome sequence analyses of Western Central African Pygmy hunter-gatherers reveal a complex demographic history and identify candidate genes under positive natural selection

  • First Published February 17, 2016
Research

Model-based analyses of whole-genome data reveal a complex evolutionary history involving archaic introgression in Central African Pygmies

  • First Published February 17, 2016
Research

Great ape Y Chromosome and mitochondrial DNA phylogenies reflect subspecies structure and patterns of mating and dispersal

  • First Published February 16, 2016
Method

A network-based analysis of colon cancer splicing changes reveals a tumorigenesis-favoring regulatory pathway emanating from ELK1

  • First Published February 9, 2016
Method

Chromosome-scale shotgun assembly using an in vitro method for long-range linkage

  • First Published February 4, 2016
Method

Models of human core transcriptional regulatory circuitries

  • First Published February 3, 2016
Research

Gene regulation and speciation in house mice

  • First Published February 1, 2016
Method

Degradation dynamics of microRNAs revealed by a novel pulse-chase approach

  • First Published January 28, 2016
Method

A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening

  • First Published January 26, 2016
Research

A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha

  • First Published January 21, 2016
Method

Genome-wide target specificities of CRISPR-Cas9 nucleases revealed by multiplex Digenome-seq

  • First Published January 19, 2016
Method

Assessment of megabase-scale somatic copy number variation using single-cell sequencing

  • First Published January 15, 2016
Method

Mapping nucleosome positions using DNase-seq

  • First Published January 15, 2016
Research

Pervasive polymorphic imprinted methylation in the human placenta

  • First Published January 14, 2016
Research

ZAK as a cause of limb defects in humans and mice" > Exome sequencing and CRISPR/Cas genome editing identify mutations of ZAK as a cause of limb defects in humans and mice

  • First Published January 11, 2016
Research

APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication

  • First Published January 11, 2016
Research

Concerted activities of Mcm4, Sld3, and Dbf4 in control of origin activation and DNA replication fork progression

  • First Published January 5, 2016
Method

Quantitative BrdU immunoprecipitation method demonstrates that Fkh1 and Fkh2 are rate-limiting activators of replication origins that reprogram replication timing in G1 phase

  • First Published January 4, 2016
Research

The life history of retrocopies illuminates the evolution of new mammalian genes

  • First Published January 4, 2016
Research

Indigenous Arabs are descendants of the earliest split from ancient Eurasian populations

  • First Published January 4, 2016
Research

TP53 regulates miRNA association with AGO2 to remodel the miRNA–mRNA interaction network

  • First Published December 23, 2015
Research

Worldwide patterns of genomic variation and admixture in gray wolves

  • First Published December 17, 2015
Research

Nasonia" > DNA methylation changes induced by long and short photoperiods in Nasonia

  • First Published December 15, 2015
Resource

Building a genomic framework for prospective MRSA surveillance in the United Kingdom and the Republic of Ireland

  • First Published December 15, 2015
Resource

Ciona intestinalis" > Genome-wide identification and characterization of transcription start sites and promoters in the tunicate Ciona intestinalis

  • First Published December 14, 2015
Method

metilene: fast and sensitive calling of differentially methylated regions from bisulfite sequencing data

  • First Published December 2, 2015
Resource

H3ABioNet, a sustainable pan-African bioinformatics network for human heredity and health in Africa

  • First Published December 1, 2015
Author Index

Author Index, Volume 25, 2015

  • First Published December 1, 2015
Reviewer Index

Reviewer Index, Volume 25, 2015

  • First Published December 1, 2015
Research

Genome-wide cooperation by HAT Gcn5, remodeler SWI/SNF, and chaperone Ydj1 in promoter nucleosome eviction and transcriptional activation

  • First Published November 24, 2015
Research

EHMT2 directs DNA methylation for efficient gene silencing in mouse embryos

  • First Published November 17, 2015
Method

cis-regulatory analysis in the mammalian central nervous system" > Massively parallel cis-regulatory analysis in the mammalian central nervous system

  • First Published November 17, 2015
Research

SCRaMbLE generates designed combinatorial stochastic diversity in synthetic chromosomes

  • First Published November 13, 2015
Research

RNA structure replaces the need for U2AF2 in splicing

  • First Published November 13, 2015
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