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In memoriam

John Sulston (1942–2018)

  • First Published June 1, 2018
Research

Long genes linked to autism spectrum disorders harbor broad enhancer-like chromatin domains

  • First Published May 30, 2018
Research

Inherited DNA methylation primes the establishment of accessible chromatin during genome activation

  • First Published May 29, 2018
Research

Evaluating recovery potential of the northern white rhinoceros from cryopreserved somatic cells

  • First Published May 24, 2018
Resource

Inversion variants in human and primate genomes

  • First Published May 18, 2018
Method

Detecting, quantifying, and discriminating the mechanism of mosaic chromosomal aneuploidies using MAD-seq

  • First Published May 17, 2018
Method

Modeling leaderless transcription and atypical genes results in more accurate gene prediction in prokaryotes

  • First Published May 17, 2018
Method

Mapping and characterizing N6-methyladenine in eukaryotic genomes using single-molecule real-time sequencing

  • First Published May 15, 2018
Method

Single-cell RNA-seq of human induced pluripotent stem cells reveals cellular heterogeneity and cell state transitions between subpopulations

  • First Published May 11, 2018
Research

Allele-specific control of replication timing and genome organization during development

  • First Published May 7, 2018
Research

The peopling of South America and the trans-Andean gene flow of the first settlers

  • First Published May 7, 2018
Method

Detection and analysis of ancient segmental duplications in mammalian genomes

  • First Published May 7, 2018
Research

A CRISPR knockout screen identifies SETDB1-target retroelement silencing factors in embryonic stem cells

  • First Published May 4, 2018
Research

The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes

  • First Published May 4, 2018
Research

RNA editing in nascent RNA affects pre-mRNA splicing

  • First Published May 3, 2018
Method

bigSCale: an analytical framework for big-scale single-cell data

  • First Published May 3, 2018
Corrigendum

Corrigendum: Evolutionary expansion of DNA hypomethylation in the mammalian germline genome

  • First Published May 1, 2018
Corrigendum

Corrigendum: Detecting differential copy number variation between groups of samples

  • First Published May 1, 2018
Corrigendum

Corrigendum: A systematic comparison reveals substantial differences in chromosomal versus episomal encoding of enhancer activity

  • First Published May 1, 2018
Research

Birth, evolution, and transmission of satellite-free mammalian centromeric domains

  • First Published April 30, 2018
Research

Molecular dissection of a natural transposable element invasion

  • First Published April 30, 2018
Method

Arrayed CRISPR screen with image-based assay reliably uncovers host genes required for coxsackievirus infection

  • First Published April 30, 2018
Resource

A comparative transcriptional landscape of maize and sorghum obtained by single-molecule sequencing

  • First Published April 30, 2018
Method

Comprehensive viral enrichment enables sensitive respiratory virus genomic identification and analysis by next generation sequencing

  • First Published April 27, 2018
Editorial

Scope note

  • First Published April 12, 2018
Resource

Hackathons as a means of accelerating scientific discoveries and knowledge transfer

  • First Published April 12, 2018
Research

Enduring epigenetic landmarks define the cancer microenvironment

  • First Published April 12, 2018
Research

HNRNPA1 promotes recognition of splice site decoys by U2AF2 in vivo

  • First Published April 12, 2018
Research

In vitro iCLIP-based modeling uncovers how the splicing factor U2AF2 relies on regulation by cofactors

  • First Published April 11, 2018
Research

L1 retrotransposition is a common feature of mammalian hepatocarcinogenesis

  • First Published April 11, 2018
Research

C. elegans and human cancers" > Mutational signatures of DNA mismatch repair deficiency in C. elegans and human cancers

  • First Published April 10, 2018
Research

In-depth characterization of the cisplatin mutational signature in human cell lines and in esophageal and liver tumors

  • First Published April 9, 2018
Perspective

Recognition of the polycistronic nature of human genes is critical to understanding the genotype-phenotype relationship

  • First Published April 6, 2018
Research

Integrated analysis sheds light on evolutionary trajectories of young transcription start sites in the human genome

  • First Published April 4, 2018
Method

Optical mapping reveals a higher level of genomic architecture of chained fusions in cancer

  • First Published April 4, 2018
Corrigendum

Corrigendum: Direct determination of diploid genome sequences

  • First Published April 2, 2018
Corrigendum

Corrigendum: Transcription rate strongly affects splicing fidelity and cotranscriptionality in budding yeast

  • First Published April 2, 2018
Commentary

The Atacama skeleton

  • First Published March 30, 2018
Method

taxMaps: comprehensive and highly accurate taxonomic classification of short-read data in reasonable time

  • First Published March 27, 2018
Method

Sequential regulatory activity prediction across chromosomes with convolutional neural networks

  • First Published March 27, 2018
Method

Double insertion of transposable elements provides a substrate for the evolution of satellite DNA

  • First Published March 27, 2018
Method

Mapping transcription factor occupancy using minimal numbers of cells in vitro and in vivo

  • First Published March 23, 2018
Research

Promoter architecture determines cotranslational regulation of mRNA

  • First Published March 22, 2018
Research

CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations" > Cancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations

  • First Published March 22, 2018
Research

Whole-genome sequencing of Atacama skeleton shows novel mutations linked with dysplasia

  • First Published March 22, 2018
Research

Mus caroli and Mus pahari genomes" > Repeat associated mechanisms of genome evolution and function revealed by the Mus caroli and Mus pahari genomes

  • First Published March 21, 2018
Research

Genome-wide determinants of sequence-specific DNA binding of general regulatory factors

  • First Published March 21, 2018
Research

Evolutionary origins and diversification of testis-specific short histone H2A variants in mammals

  • First Published March 16, 2018
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