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Method

Quantitative mitochondrial DNA copy number determination using droplet digital PCR with single-cell resolution

  • First Published September 23, 2019
Research

Regional epigenetic differentiation of the Z Chromosome between sexes in a female heterogametic system

  • First Published September 23, 2019
Research

Saccharomyces hybrids" > Fitness benefits of loss of heterozygosity in Saccharomyces hybrids

  • First Published September 23, 2019
Resource

Discovery of high-confidence human protein-coding genes and exons by whole-genome PhyloCSF helps elucidate 118 GWAS loci

  • First Published September 19, 2019
Research

The strand-biased mitochondrial DNA methylome and its regulation by DNMT3A

  • First Published September 19, 2019
Research

LTR retroelement expansion of the human cancer transcriptome and immunopeptidome revealed by de novo transcript assembly

  • First Published September 19, 2019
Research

Transcriptional alterations in glioma result primarily from DNA methylation–independent mechanisms

  • First Published September 18, 2019
Research

Sequence determinants of polyadenylation-mediated regulation

  • First Published September 17, 2019
Research

Nascent transcript analysis of glucocorticoid crosstalk with TNF defines primary and cooperative inflammatory repression

  • First Published September 13, 2019
Method

Gene expression profiling of single cells from archival tissue with laser-capture microdissection and Smart-3SEQ

  • First Published September 13, 2019
Research

Global analyses of the dynamics of mammalian microRNA metabolism

  • First Published September 13, 2019
Research

A-to-I RNA editing contributes to the persistence of predicted damaging mutations in populations

  • First Published September 12, 2019
Method

A novel assay to screen siRNA libraries identifies protein kinases required for chromosome transmission

  • First Published September 12, 2019
Research

Dynamic reversal of random X-Chromosome inactivation during iPSC reprogramming

  • First Published September 12, 2019
Research

Accessibility of promoter DNA is not the primary determinant of chromatin-mediated gene regulation

  • First Published September 11, 2019
Research

The 22q11 low copy repeats are characterized by unprecedented size and structural variability

  • First Published September 3, 2019
Corrigendum

C. elegans and human cancers" > Corrigendum: Mutational signatures of DNA mismatch repair deficiency in C. elegans and human cancers

  • First Published September 3, 2019
Method

Discovering human transcription factor physical interactions with genetic variants, novel DNA motifs, and repetitive elements using enhanced yeast one-hybrid assays

  • First Published September 3, 2019
Corrigendum

Drosophila melanogaster" > Corrigendum: A long-term demasculinization of X-linked intergenic noncoding RNAs in Drosophila melanogaster

  • First Published September 3, 2019
Research

Saccharomyces cerevisiae var. boulardii" > Unique genetic basis of the distinct antibiotic potency of high acetic acid production in the probiotic yeast Saccharomyces cerevisiae var. boulardii

  • First Published August 29, 2019
Method

Direct RNA nanopore sequencing of full-length coronavirus genomes provides novel insights into structural variants and enables modification analysis

  • First Published August 22, 2019
Resource

Pediatric Cancer Variant Pathogenicity Information Exchange (PeCanPIE): a cloud-based platform for curating and classifying germline variants

  • First Published August 22, 2019
Research

Escherichia coli reveals that bovine-adapted E. coli lineages are serving as evolutionary sources of the emergence of human intestinal pathogenic strains" > Large-scale genome analysis of bovine commensal Escherichia coli reveals that bovine-adapted E. coli lineages are serving as evolutionary sources of the emergence of human intestinal pathogenic strains

  • First Published August 22, 2019
Resource

Exploration of fine-scale recombination rate variation in the domestic horse

  • First Published August 21, 2019
Research

RNA components of the spliceosome regulate tissue- and cancer-specific alternative splicing

  • First Published August 21, 2019
Research

Replication timing networks reveal a link between transcription regulatory circuits and replication timing control

  • First Published August 21, 2019
Perspective

Decrypting noncoding RNA interactions, structures, and functional networks

  • First Published August 21, 2019
Research

A high resolution A-to-I editing map in the mouse identifies editing events controlled by pre-mRNA splicing

  • First Published August 19, 2019
Research

Distinct types of short open reading frames are translated in plant cells

  • First Published August 6, 2019
Research

Estrogen-independent molecular actions of mutant estrogen receptor 1 in endometrial cancer

  • First Published July 30, 2019
Method

Identifying loci under positive selection in complex population histories

  • First Published July 30, 2019
Research

Whole-genome sequencing reveals high complexity of copy number variation at insecticide resistance loci in malaria mosquitoes

  • First Published July 25, 2019
Resource

Benchmark and integration of resources for the estimation of human transcription factor activities

  • First Published July 24, 2019
Research

Glucocorticoid receptor quaternary structure drives chromatin occupancy and transcriptional outcome

  • First Published July 23, 2019
Method

Profiling the long noncoding RNA interaction network in the regulatory elements of target genes by chromatin in situ reverse transcription sequencing

  • First Published July 17, 2019
Research

Characterization of functional relationships of R-loops with gene transcription and epigenetic modifications in rice

  • First Published July 1, 2019
Research

High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma

  • First Published June 27, 2019
Research

Local features determine Ty3 targeting frequency at RNA polymerase III transcription start sites

  • First Published June 27, 2019
Research

Drosophila populations" > Circadian gene variants and the skeletal muscle circadian clock contribute to the evolutionary divergence in longevity across Drosophila populations

  • First Published June 27, 2019
Method

Efficient and flexible tagging of endogenous genes by homology-independent intron targeting

  • First Published June 25, 2019
Research

Capture of a functionally active methyl-CpG binding domain by an arthropod retrotransposon family

  • First Published June 25, 2019
Method

Genetic variant pathogenicity prediction trained using disease-specific clinical sequencing data sets

  • First Published June 24, 2019
Method

OMA standalone: orthology inference among public and custom genomes and transcriptomes

  • First Published June 24, 2019
Research

Exome-wide assessment of the functional impact and pathogenicity of multinucleotide mutations

  • First Published June 21, 2019
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