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Method

Genome assembly quality: Assessment and improvement using the neutral indel model

  • First Published March 19, 2010
Research

Deep RNA sequencing at single base-pair resolution reveals high complexity of the rice transcriptome

  • First Published March 19, 2010
Research

Pristionchus pacificus reveals distinct proteome structure of nematode models" > Proteogenomics of Pristionchus pacificus reveals distinct proteome structure of nematode models

  • First Published March 17, 2010
Research

Rewirable gene regulatory networks in the preimplantation embryonic development of three mammalian species

  • First Published March 10, 2010
Research

The (r)evolution of SINE versus LINE distributions in primate genomes: Sex chromosomes are important

  • First Published March 10, 2010
Research

A CTCF-independent role for cohesin in tissue-specific transcription

  • First Published March 10, 2010
Research

Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer

  • First Published March 10, 2010
Method

Integrating multiple evidence sources to predict transcription factor binding in the human genome

  • First Published March 10, 2010
Research

Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains

  • First Published March 10, 2010
Research

Ciona intestinalis SL trans-spliced mRNAs: Alternative expression modes and gene function correlates" > High-throughput sequence analysis of Ciona intestinalis SL trans-spliced mRNAs: Alternative expression modes and gene function correlates

  • First Published March 8, 2010
Research

The effect of translocation-induced nuclear reorganization on gene expression

  • First Published March 8, 2010
Resource

Analysis of copy number variations among diverse cattle breeds

  • First Published March 8, 2010
Research

Coexpression network analysis of neural tissue reveals perturbations in developmental processes in schizophrenia

  • First Published March 2, 2010
RESOURCE

An effective model for natural selection in promoters

  • First Published March 1, 2010
Research

Genome-wide analysis of histone modifications in human pancreatic islets

  • First Published February 24, 2010
Research

Integrative analysis of the melanoma transcriptome

  • First Published February 23, 2010
Resource

Accurate detection and genotyping of SNPs utilizing population sequencing data

  • First Published February 11, 2010
Methods

Inference of RhoGAP/GTPase regulation using single-cell morphological data from a combinatorial RNAi screen

  • First Published February 9, 2010
Method

Digital transcriptome profiling from attomole-level RNA samples

  • First Published February 4, 2010
Letter

Dynamic changes in the human methylome during differentiation

  • First Published February 4, 2010
Methods

A new strategy for genome assembly using short sequence reads and reduced representation libraries

  • First Published February 1, 2010
Letter

ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells

  • First Published January 28, 2010
Letter

Widespread and tissue specific age-related DNA methylation changes in mice

  • First Published January 27, 2010
Research

Impact of replication timing on non-CpG and CpG substitution rates in mammalian genomes

  • First Published January 26, 2010
Letter

Copy number abnormalities in sporadic canine colorectal cancers

  • First Published January 19, 2010
Methods

Population differentiation as a test for selective sweeps

  • First Published January 19, 2010
Methods

Genome-wide discovery of human heart enhancers

  • First Published January 14, 2010
Review

Population genetic inference from genomic sequence variation

  • First Published January 12, 2010
Letter

Evolutionary constraint facilitates interpretation of genetic variation in resequenced human genomes

  • First Published January 12, 2010
Research

Genome-wide evidence for selection acting on single amino acid repeats

  • First Published January 7, 2010
Resource

A high-resolution association mapping panel for the dissection of complex traits in mice

  • First Published January 6, 2010
Letter

Nucleosome landscape and control of transcription in the human malaria parasite

  • First Published January 6, 2010
Methods

Cross-mapping and the identification of editing sites in mature microRNAs in high-throughput sequencing libraries

  • First Published January 5, 2010
Letter

Human genetic variation recognizes functional elements in noncoding sequence

  • First Published December 23, 2009
Letter

Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus

  • First Published December 22, 2009
Resource

A SNP discovery method to assess variant allele probability from next-generation resequencing data

  • First Published December 17, 2009
Resource

De novo assembly of human genomes with massively parallel short read sequencing

  • First Published December 17, 2009
Letter

Sex-specific and lineage-specific alternative splicing in primates

  • First Published December 15, 2009
Letter

Bayesian network analysis of targeting interactions in chromatin

  • First Published December 9, 2009
Letter

Drosophila ORC localizes to open chromatin and marks sites of cohesin complex loading" > Drosophila ORC localizes to open chromatin and marks sites of cohesin complex loading

  • First Published December 7, 2009
Article

Genome-wide dynamics of replication timing revealed by in vitro models of mouse embryogenesis

  • First Published December 1, 2009
Letter

Ecological adaptation determines functional mammalian olfactory subgenomes

  • First Published December 1, 2009
Methods

Estimating population genetic parameters and comparing model goodness-of-fit using DNA sequences with error

  • First Published December 1, 2009
Letter

Extreme variability among mammalian V1R gene families

  • First Published December 1, 2009
Methods

Targeted chromosomal deletions in human cells using zinc finger nucleases

  • First Published December 1, 2009
Errata

Errata

  • First Published December 1, 2009
Methods

Reconstructing ancestral gene content by coevolution

  • First Published November 30, 2009
Letter

Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination

  • First Published November 19, 2009
Letter

Bhmt2 as a diet-dependent genetic factor protecting against acetaminophen-induced liver toxicity" > An integrative genomic analysis identifies Bhmt2 as a diet-dependent genetic factor protecting against acetaminophen-induced liver toxicity

  • First Published November 18, 2009
Methods

Inferring tumor progression from genomic heterogeneity

  • First Published November 10, 2009
Letter

Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype" > Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype

  • First Published November 9, 2009
Letter

Industrial fuel ethanol yeasts contain adaptive copy number changes in genes involved in vitamin B1 and B6 biosynthesis

  • First Published November 6, 2009
Letter

A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains

  • First Published November 3, 2009
Letter

DNA methylation programming and reprogramming in primate embryonic stem cells

  • First Published November 3, 2009
Article

Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression

  • First Published November 3, 2009
Resource

A single-base resolution map of an archaeal transcriptome

  • First Published November 2, 2009
Methods

Detection of nonneutral substitution rates on mammalian phylogenies

  • First Published October 26, 2009
Letter

A novel strategy of transcription regulation by intragenic nucleosome ordering

  • First Published October 26, 2009
Letter

Arabidopsis thaliana" > Genome-wide mapping of alternative splicing in Arabidopsis thaliana

  • First Published October 26, 2009
Resource

ProPhylER: A curated online resource for protein function and structure based on evolutionary constraint analyses

  • First Published October 21, 2009
Methods

High-resolution nucleosome mapping reveals transcription-dependent promoter packaging

  • First Published October 21, 2009
Methods

Salmonella Typhi gene using one million transposon mutants" > Simultaneous assay of every Salmonella Typhi gene using one million transposon mutants

  • First Published October 13, 2009
Resource

The NIH Human Microbiome Project

  • First Published October 9, 2009
Letter

Human capacitance to dosage imbalance: Coping with inefficient selection

  • First Published October 9, 2009
Resource

Windshield splatter analysis with the Galaxy metagenomic pipeline

  • First Published October 9, 2009
Letter

Saccharomyces cerevisiae strain widely used in bioethanol production" > Genome structure of a Saccharomyces cerevisiae strain widely used in bioethanol production

  • First Published October 7, 2009
Perspective

Phylogenomics of primates and their ancestral populations

  • First Published October 3, 2009
Methods

Rapid inexpensive genome-wide association using pooled whole blood

  • First Published October 3, 2009
Article

Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation

  • First Published October 2, 2009
Letter

Saccharomyces cerevisiae" > A positive but complex association between meiotic double-strand break hotspots and open chromatin in Saccharomyces cerevisiae

  • First Published October 2, 2009
Resource

C. elegans ORFeome" > Large-scale RACE approach for proactive experimental definition of C. elegans ORFeome

  • First Published October 2, 2009
Commentary

Darwinian alchemy: Human genes from noncoding DNA

  • First Published October 1, 2009
Letter

Coexpression network based on natural variation in human gene expression reveals gene interactions and functions

  • First Published October 1, 2009
Methods

Automatic analysis of dividing cells in live cell movies to detect mitotic delays and correlate phenotypes in time

  • First Published October 1, 2009
Methods

Rapid identification of homologous recombinants and determination of gene copy number with reference/query pyrosequencing (RQPS)

  • First Published October 1, 2009
Letter

Do genetic recombination and gene density shape the pattern of DNA elimination in rice long terminal repeat retrotransposons?

  • First Published September 29, 2009
Resource

The completion of the Mammalian Gene Collection (MGC)

  • First Published September 18, 2009
Methods

Predictable dynamic program of timing of DNA replication in human cells

  • First Published September 18, 2009
Letter

Relative contribution of sequence and structure features to the mRNA binding of Argonaute/EIF2C–miRNA complexes and the degradation of miRNA targets

  • First Published September 18, 2009
Letter

Repertoire and evolution of miRNA genes in four divergent nematode species

  • First Published September 15, 2009
Methods

Two-parameter characterization of chromosome-scale recombination rate

  • First Published September 14, 2009
Letter

Candida dubliniensis and Candida albicans" > Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans

  • First Published September 10, 2009
Letter

Complex selection on 5′ splice sites in intron-rich organisms

  • First Published September 10, 2009
Letter

Rapid evolution of mouse Y centromere repeat DNA belies recent sequence stability

  • First Published September 8, 2009
Letter

Recent de novo origin of human protein-coding genes

  • First Published September 2, 2009
Erratum

Erratum

  • First Published September 1, 2009
Methods

An ensemble model of competitive multi-factor binding of the genome

  • First Published August 31, 2009
Letter

Coccidioides and their relatives" > Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives

  • First Published August 28, 2009
Letter

Chromatin poises miRNA- and protein-coding genes for expression

  • First Published August 27, 2009
Letter

Deeply conserved chordate noncoding sequences preserve genome synteny but do not drive gene duplicate retention

  • First Published August 24, 2009
Resource

Singapore Genome Variation Project: A haplotype map of three Southeast Asian populations

  • First Published August 21, 2009
Methods

The human protein coevolution network

  • First Published August 20, 2009
Letter

Elucidation of the ELK1 target gene network reveals a role in the coordinate regulation of core components of the gene regulation machinery

  • First Published August 17, 2009
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