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Research

Drosophila" > Extensive cross-regulation of post-transcriptional regulatory networks in Drosophila

  • First Published August 20, 2015
Research

Tandem repeat variation in human and great ape populations and its impact on gene expression divergence

  • First Published August 19, 2015
Resource

Genome-wide annotation of microRNA primary transcript structures reveals novel regulatory mechanisms

  • First Published August 19, 2015
Method

Read clouds uncover variation in complex regions of the human genome

  • First Published August 18, 2015
Research

GC skew defines distinct RNA polymerase pause sites in CpG island promoters

  • First Published August 14, 2015
Research

Widespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution

  • First Published August 10, 2015
Research

Genetic and environmental control of host-gut microbiota interactions

  • First Published August 10, 2015
Research

Chlamydomonas reinhardtii" > Extensive de novo mutation rate variation between individuals and across the genome of Chlamydomonas reinhardtii

  • First Published August 10, 2015
Method

The use of exome capture RNA-seq for highly degraded RNA with application to clinical cancer sequencing

  • First Published August 7, 2015
Corrigendum

Corrigendum: MIPSTR: a method for multiplex genotyping of germline and somatic STR variation across many individuals

  • First Published August 3, 2015
Research

Comparison against 186 canid whole-genome sequences reveals survival strategies of an ancient clonally transmissible canine tumor

  • First Published July 31, 2015
Research

C. elegans" > Cooperative target mRNA destabilization and translation inhibition by miR-58 microRNA family in C. elegans

  • First Published July 31, 2015
Research

The frequent evolutionary birth and death of functional promoters in mouse and human

  • First Published July 30, 2015
Method

Discriminating somatic and germline mutations in tumor DNA samples without matching normals

  • First Published July 24, 2015
Research

Aedes aegypti by deep targeted sequencing" > Identifying genomic changes associated with insecticide resistance in the dengue mosquito Aedes aegypti by deep targeted sequencing

  • First Published July 23, 2015
Research

Evolution of selenophosphate synthetases: emergence and relocation of function through independent duplications and recurrent subfunctionalization

  • First Published July 20, 2015
Research

Dynamics and function of distal regulatory elements during neurogenesis and neuroplasticity

  • First Published July 13, 2015
Method

Saturation analysis of ChIP-seq data for reproducible identification of binding peaks

  • First Published July 10, 2015
Research

A widespread role of the motif environment in transcription factor binding across diverse protein families

  • First Published July 9, 2015
Research

SETDB1 modulates PRC2 activity at developmental genes independently of H3K9 trimethylation in mouse ES cells

  • First Published July 9, 2015
Research

Streptococcus equi, is driven by persistent infection" > Genome specialization and decay of the strangles pathogen, Streptococcus equi, is driven by persistent infection

  • First Published July 9, 2015
Research

Functional compensation among HMGN variants modulates the DNase I hypersensitive sites at enhancers

  • First Published July 8, 2015
Research

Germline mutation rates and the long-term phenotypic effects of mutation accumulation in wild-type laboratory mice and mutator mice

  • First Published June 30, 2015
Research

Genome-wide analysis of translational efficiency reveals distinct but overlapping functions of yeast DEAD-box RNA helicases Ded1 and eIF4A

  • First Published June 29, 2015
Research

Acute TNF-induced repression of cell identity genes is mediated by NFκB-directed redistribution of cofactors from super-enhancers

  • First Published June 25, 2015
Research

Comprehensive identification and analysis of human accelerated regulatory DNA

  • First Published June 23, 2015
Method

Massively parallel quantification of the regulatory effects of noncoding genetic variation in a human cohort

  • First Published June 17, 2015
Research

Unbalanced translocations arise from diverse mutational mechanisms including chromothripsis

  • First Published June 12, 2015
Research

Determinants of nucleosome positioning and their influence on plant gene expression

  • First Published June 10, 2015
Research

Sequence determinants of improved CRISPR sgRNA design

  • First Published June 10, 2015
Resource

The landscape of antisense gene expression in human cancers

  • First Published June 10, 2015
Research

Using genome-wide measures of coancestry to maintain diversity and fitness in endangered and domestic pig populations

  • First Published June 10, 2015
Research

Dynamic changes in replication timing and gene expression during lineage specification of human pluripotent stem cells

  • First Published June 8, 2015
Research

The sea lamprey meiotic map improves resolution of ancient vertebrate genome duplications

  • First Published June 5, 2015
Research

Regulation of the ESC transcriptome by nuclear long noncoding RNAs

  • First Published June 5, 2015
Method

High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9

  • First Published June 5, 2015
Research

Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators

  • First Published May 29, 2015
Resource

Hox clusters in ES cells" > Analysis of dynamic changes in retinoid-induced transcription and epigenetic profiles of murine Hox clusters in ES cells

  • First Published May 29, 2015
Research

Topologically associating domains and their long-range contacts are established during early G1 coincident with the establishment of the replication-timing program

  • First Published May 20, 2015
Research

Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites

  • First Published May 20, 2015
Method

Quantification of GC-biased gene conversion in the human genome

  • First Published May 20, 2015
Research

Genome-wide activities of Polycomb complexes control pervasive transcription

  • First Published May 18, 2015
Method

CheckM: assessing the quality of microbial genomes recovered from isolates, single cells, and metagenomes

  • First Published May 14, 2015
Research

Core promoter sequence in yeast is a major determinant of expression level

  • First Published May 12, 2015
Research

Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells

  • First Published May 11, 2015
Research

Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo

  • First Published May 8, 2015
Research

The landscape of genomic imprinting across diverse adult human tissues

  • First Published May 7, 2015
Research

Unmasking alternative splicing inside protein-coding exons defines exitrons and their role in proteome plasticity

  • First Published May 1, 2015
Resource

Using populations of human and microbial genomes for organism detection in metagenomes

  • First Published April 29, 2015
Research

C. elegans" > Coordinated tissue-specific regulation of adjacent alternative 3′ splice sites in C. elegans

  • First Published April 28, 2015
Research

Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders

  • First Published April 27, 2015
Method

A pooling-based approach to mapping genetic variants associated with DNA methylation

  • First Published April 24, 2015
Method

Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity

  • First Published April 23, 2015
Research

The clustering of functionally related genes contributes to CNV-mediated disease

  • First Published April 17, 2015
Method

An efficient and scalable analysis framework for variant extraction and refinement from population-scale DNA sequence data

  • First Published April 16, 2015
Research

Widespread exon skipping triggers degradation by nuclear RNA surveillance in fission yeast

  • First Published April 16, 2015
Research

Characterization and dynamics of pericentromere-associated domains in mice

  • First Published April 16, 2015
Research

Antagonistic regulation of mRNA expression and splicing by CELF and MBNL proteins

  • First Published April 16, 2015
Research

Characteristics of de novo structural changes in the human genome

  • First Published April 16, 2015
Research

Germline and somatic imprinting in the nonhuman primate highlights species differences in oocyte methylation

  • First Published April 10, 2015
Research

C. albicans infection in various niches" > New signaling pathways govern the host response to C. albicans infection in various niches

  • First Published April 9, 2015
Method

Optimizing sparse sequencing of single cells for highly multiplex copy number profiling

  • First Published April 9, 2015
Erratum

Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles" > Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles

  • First Published April 1, 2015
Erratum

BRF1 mutations alter RNA polymerase III–dependent transcription and cause neurodevelopmental anomalies" > BRF1 mutations alter RNA polymerase III–dependent transcription and cause neurodevelopmental anomalies

  • First Published April 1, 2015
Method

Accurate typing of short tandem repeats from genome-wide sequencing data and its applications

  • First Published March 30, 2015
Research

Arabidopsis and humans" > Organelle DNA rearrangement mapping reveals U-turn-like inversions as a major source of genomic instability in Arabidopsis and humans

  • First Published March 23, 2015
Research

Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes

  • First Published March 23, 2015
Research

Global variability in gene expression and alternative splicing is modulated by mitochondrial content

  • First Published March 23, 2015
Research

Evidence for widespread subfunctionalization of splice forms in vertebrate genomes

  • First Published March 19, 2015
Research

Extensive microRNA-mediated crosstalk between lncRNAs and mRNAs in mouse embryonic stem cells

  • First Published March 19, 2015
Research

Caenorhabditis" > Full-genome evolutionary histories of selfing, splitting, and selection in Caenorhabditis

  • First Published March 17, 2015
Research

A nucleosome turnover map reveals that the stability of histone H4 Lys20 methylation depends on histone recycling in transcribed chromatin

  • First Published March 16, 2015
Research

A recent bottleneck of Y chromosome diversity coincides with a global change in culture

  • First Published March 13, 2015
Method

Effect of minichromosome maintenance protein 2 deficiency on the locations of DNA replication origins

  • First Published March 11, 2015
Research

h chromosome" > Origin and domestication of papaya Yh chromosome

  • First Published March 11, 2015
Method

Unraveling determinants of transcription factor binding outside the core binding site

  • First Published March 11, 2015
Resource

The pluripotent regulatory circuitry connecting promoters to their long-range interacting elements

  • First Published March 9, 2015
Research

The role of DNA methylation in directing the functional organization of the cancer epigenome

  • First Published March 6, 2015
Research

ChIP-exo signal associated with DNA-binding motifs provides insight into the genomic binding of the glucocorticoid receptor and cooperating transcription factors

  • First Published February 26, 2015
Research

Dynamics of chromatin accessibility and long-range interactions in response to glucocorticoid pulsing

  • First Published February 12, 2015
Method

Joint annotation of chromatin state and chromatin conformation reveals relationships among domain types and identifies domains of cell-type-specific expression

  • First Published February 12, 2015
Research

Spatial enhancer clustering and regulation of enhancer-proximal genes by cohesin

  • First Published February 12, 2015
Method

Detection and phasing of single base de novo mutations in biopsies from human in vitro fertilized embryos by advanced whole-genome sequencing

  • First Published February 11, 2015
Research

Accurate, multi-kb reads resolve complex populations and detect rare microorganisms

  • First Published February 9, 2015
Method

MIPSTR: a method for multiplex genotyping of germline and somatic STR variation across many individuals

  • First Published February 6, 2015
Method

Bacterial genome reduction using the progressive clustering of deletions via yeast sexual cycling

  • First Published February 5, 2015
Research

The inactive X chromosome is epigenetically unstable and transcriptionally labile in breast cancer

  • First Published February 4, 2015
Research

DNA methylation at hepatitis B viral integrants is associated with methylation at flanking human genomic sequences

  • First Published February 4, 2015
Research

Methylomic trajectories across human fetal brain development

  • First Published February 3, 2015
Research

The spatial and temporal organization of origin firing during the S-phase of fission yeast

  • First Published February 3, 2015
Research

Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution

  • First Published February 3, 2015
Research

Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers

  • First Published February 2, 2015
Method

Model-driven mapping of transcriptional networks reveals the circuitry and dynamics of virulence regulation

  • First Published February 2, 2015
Research

Actionable exomic incidental findings in 6503 participants: challenges of variant classification

  • First Published January 30, 2015
Research

A systems-level approach to parental genomic imprinting: the imprinted gene network includes extracellular matrix genes and regulates cell cycle exit and differentiation

  • First Published January 22, 2015
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