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Review

Artificial intelligence and machine learning in cell-free-DNA-based diagnostics

  • W.H. Adrian Tsui
  • Spencer C. Ding
  • Peiyong Jiang
  • Y.M. Dennis Lo
  • First Published January 22, 2025
Research

Analysis of a cell-free DNA–based cancer screening cohort links fragmentomic profiles, nuclease levels, and plasma DNA concentrations

  • Yasine Malki
  • Guannan Kang
  • W.K. Jacky Lam
  • Qing Zhou
  • Suk Hang Cheng
  • Peter P.H. Cheung Jinyue Bai Ming Lok Chan Chui Ting Lee Wenlei Peng Yiqiong Zhang Wanxia Gai Winsome W.S. Wong Mary-Jane L. Ma Wenshuo Li Xinzhou Xu Zhuoran Gao Irene O.L. Tse Huimin Shang
  • ... [+14 authors] ...,
  • L.Y. Lois Choy
  • Peiyong Jiang
  • K.C. Allen Chan
  • Y.M. Dennis Lo
  • First Published November 27, 2024
Research

Genomic origin, fragmentomics, and transcriptional properties of long cell-free DNA molecules in human plasma

  • Huiwen Che
  • Peiyong Jiang
  • L.Y. Lois Choy
  • Suk Hang Cheng
  • Wenlei Peng
  • Rebecca W.Y. Chan Jing Liu Qing Zhou W.K. Jacky Lam Stephanie C.Y. Yu So Ling Lau Tak Y. Leung John Wong Vincent Wai-Sun Wong
  • ... [+9 authors] ...,
  • Grace L.H. Wong
  • Stephen L. Chan
  • K.C. Allen Chan
  • Y.M. Dennis Lo
  • First Published February 26, 2024
Research

Nuclease deficiencies alter plasma cell-free DNA methylation profiles

  • Diana S.C. Han
  • Meng Ni
  • Rebecca W.Y. Chan
  • Danny K.L. Wong
  • Linda T. Hiraki
  • Stefano Volpi Peiyong Jiang
  • ... [+2 authors] ...,
  • Kathy O. Lui
  • K.C. Allen Chan
  • Rossa W.K. Chiu
  • Y.M. Dennis Lo
  • First Published September 1, 2021
Method

Detection and characterization of jagged ends of double-stranded DNA in plasma

  • Peiyong Jiang
  • Tingting Xie
  • Spencer C. Ding
  • Ze Zhou
  • Suk Hang Cheng
  • Rebecca W.Y. Chan Wing-Shan Lee Wenlei Peng John Wong Vincent W.S. Wong Henry L.Y. Chan Stephen L. Chan Liona C.Y. Poon
  • ... [+8 authors] ...,
  • Tak Y. Leung
  • K.C. Allen Chan
  • Rossa W.K. Chiu
  • Y.M. Dennis Lo
  • First Published August 14, 2020
Method

Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin

  • Kun Sun
  • Peiyong Jiang
  • Suk Hang Cheng
  • Timothy H.T. Cheng
  • John Wong
  • Vincent W.S. Wong Simon S.M. Ng Brigette B.Y. Ma Tak Y. Leung Stephen L. Chan Tony S.K. Mok Paul B.S. Lai Henry L.Y. Chan
  • ... [+8 authors] ...,
  • Hao Sun
  • K.C. Allen Chan
  • Rossa W.K. Chiu
  • Y.M. Dennis Lo
  • First Published February 26, 2019
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