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Review

Artificial intelligence and machine learning in cell-free-DNA-based diagnostics

W.H. Adrian Tsui
Spencer C. Ding
Peiyong Jiang
Y.M. Dennis Lo

First Published January 22, 2025

Research

Analysis of a cell-free DNA–based cancer screening cohort links fragmentomic profiles, nuclease levels, and plasma DNA concentrations

Yasine Malki
Guannan Kang
W.K. Jacky Lam
Qing Zhou
Suk Hang Cheng
Peter P.H. Cheung Jinyue Bai Ming Lok Chan Chui Ting Lee Wenlei Peng Yiqiong Zhang Wanxia Gai Winsome W.S. Wong Mary-Jane L. Ma Wenshuo Li Xinzhou Xu Zhuoran Gao Irene O.L. Tse Huimin Shang
... [+14 authors] ...,
L.Y. Lois Choy
Peiyong Jiang
K.C. Allen Chan
Y.M. Dennis Lo

First Published November 27, 2024

Research

Genomic origin, fragmentomics, and transcriptional properties of long cell-free DNA molecules in human plasma

Huiwen Che
Peiyong Jiang
L.Y. Lois Choy
Suk Hang Cheng
Wenlei Peng
Rebecca W.Y. Chan Jing Liu Qing Zhou W.K. Jacky Lam Stephanie C.Y. Yu So Ling Lau Tak Y. Leung John Wong Vincent Wai-Sun Wong
... [+9 authors] ...,
Grace L.H. Wong
Stephen L. Chan
K.C. Allen Chan
Y.M. Dennis Lo

First Published February 26, 2024

Research

Nuclease deficiencies alter plasma cell-free DNA methylation profiles

Diana S.C. Han
Meng Ni
Rebecca W.Y. Chan
Danny K.L. Wong
Linda T. Hiraki
Stefano Volpi Peiyong Jiang
... [+2 authors] ...,
Kathy O. Lui
K.C. Allen Chan
Rossa W.K. Chiu
Y.M. Dennis Lo

First Published September 1, 2021

Method

Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin

Kun Sun
Peiyong Jiang
Suk Hang Cheng
Timothy H.T. Cheng
John Wong
Vincent W.S. Wong Simon S.M. Ng Brigette B.Y. Ma Tak Y. Leung Stephen L. Chan Tony S.K. Mok Paul B.S. Lai Henry L.Y. Chan
... [+8 authors] ...,
Hao Sun
K.C. Allen Chan
Rossa W.K. Chiu
Y.M. Dennis Lo

First Published February 26, 2019