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Review

Artificial intelligence and machine learning in cell-free-DNA-based diagnostics

W.H. Adrian Tsui
Spencer C. Ding
Peiyong Jiang
Y.M. Dennis Lo

First Published January 22, 2025

Research

Analysis of a cell-free DNA–based cancer screening cohort links fragmentomic profiles, nuclease levels, and plasma DNA concentrations

Yasine Malki
Guannan Kang
W.K. Jacky Lam
Qing Zhou
Suk Hang Cheng
Peter P.H. Cheung Jinyue Bai Ming Lok Chan Chui Ting Lee Wenlei Peng Yiqiong Zhang Wanxia Gai Winsome W.S. Wong Mary-Jane L. Ma Wenshuo Li Xinzhou Xu Zhuoran Gao Irene O.L. Tse Huimin Shang
... [+14 authors] ...,
L.Y. Lois Choy
Peiyong Jiang
K.C. Allen Chan
Y.M. Dennis Lo

First Published November 27, 2024

Research

Genomic origin, fragmentomics, and transcriptional properties of long cell-free DNA molecules in human plasma

Huiwen Che
Peiyong Jiang
L.Y. Lois Choy
Suk Hang Cheng
Wenlei Peng
Rebecca W.Y. Chan Jing Liu Qing Zhou W.K. Jacky Lam Stephanie C.Y. Yu So Ling Lau Tak Y. Leung John Wong Vincent Wai-Sun Wong
... [+9 authors] ...,
Grace L.H. Wong
Stephen L. Chan
K.C. Allen Chan
Y.M. Dennis Lo

First Published February 26, 2024

Research

Nuclease deficiencies alter plasma cell-free DNA methylation profiles

Diana S.C. Han
Meng Ni
Rebecca W.Y. Chan
Danny K.L. Wong
Linda T. Hiraki
Stefano Volpi Peiyong Jiang
... [+2 authors] ...,
Kathy O. Lui
K.C. Allen Chan
Rossa W.K. Chiu
Y.M. Dennis Lo

First Published September 1, 2021

Method

Detection and characterization of jagged ends of double-stranded DNA in plasma

Peiyong Jiang
Tingting Xie
Spencer C. Ding
Ze Zhou
Suk Hang Cheng
Rebecca W.Y. Chan Wing-Shan Lee Wenlei Peng John Wong Vincent W.S. Wong Henry L.Y. Chan Stephen L. Chan Liona C.Y. Poon
... [+8 authors] ...,
Tak Y. Leung
K.C. Allen Chan
Rossa W.K. Chiu
Y.M. Dennis Lo

First Published August 14, 2020

Method

Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin

Kun Sun
Peiyong Jiang
Suk Hang Cheng
Timothy H.T. Cheng
John Wong
Vincent W.S. Wong Simon S.M. Ng Brigette B.Y. Ma Tak Y. Leung Stephen L. Chan Tony S.K. Mok Paul B.S. Lai Henry L.Y. Chan
... [+8 authors] ...,
Hao Sun
K.C. Allen Chan
Rossa W.K. Chiu
Y.M. Dennis Lo

First Published February 26, 2019

Research

Yeast genetic interaction screen of human genes associated with amyotrophic lateral sclerosis: identification of MAP2K5 kinase as a potential drug target

Myungjin Jo
Ah Young Chung
Nozomu Yachie
Minchul Seo
Hyejin Jeon
Youngpyo Nam Yeojin Seo Eunmi Kim Quan Zhong
... [+4 authors] ...,
Marc Vidal
Hae Chul Park
Frederick P. Roth
Kyoungho Suk

First Published June 8, 2017

Method

An extended set of yeast-based functional assays accurately identifies human disease mutations

Song Sun
Fan Yang
Guihong Tan
Michael Costanzo
Rose Oughtred
Jodi Hirschman Chandra L. Theesfeld Pritpal Bansal Nidhi Sahni Song Yi Analyn Yu Tanya Tyagi Cathy Tie David E. Hill Marc Vidal
... [+10 authors] ...,
Brenda J. Andrews
Charles Boone
Kara Dolinski
Frederick P. Roth

First Published March 14, 2016

Resource

C. elegans ORFeome" > Large-scale RACE approach for proactive experimental definition of C. elegans ORFeome

Kourosh Salehi-Ashtiani
Chenwei Lin
Tong Hao
Yun Shen
David Szeto
Xinping Yang Lila Ghamsari HanJoo Lee Changyu Fan Ryan R. Murray Stuart Milstein Nenad Svrzikapa
... [+7 authors] ...,
Michael E. Cusick
Frederick P. Roth
David E. Hill
Marc Vidal

First Published October 2, 2009

Resource

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network

Gabriel Markson
Christina Kiel
Russell Hyde
Stephanie Brown
Panagoula Charalabous
Anja Bremm Jennifer Semple Jonathan Woodsmith Simon Duley Kourosh Salehi-Ashtiani Marc Vidal
... [+6 authors] ...,
David Komander
Luis Serrano
Paul Lehner
Christopher M. Sanderson

First Published June 23, 2009

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