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Research

Yeast genetic interaction screen of human genes associated with amyotrophic lateral sclerosis: identification of MAP2K5 kinase as a potential drug target

Myungjin Jo
Ah Young Chung
Nozomu Yachie
Minchul Seo
Hyejin Jeon
Youngpyo Nam Yeojin Seo Eunmi Kim Quan Zhong
... [+4 authors] ...,
Marc Vidal
Hae Chul Park
Frederick P. Roth
Kyoungho Suk

First Published June 8, 2017

Method

An extended set of yeast-based functional assays accurately identifies human disease mutations

Song Sun
Fan Yang
Guihong Tan
Michael Costanzo
Rose Oughtred
Jodi Hirschman Chandra L. Theesfeld Pritpal Bansal Nidhi Sahni Song Yi Analyn Yu Tanya Tyagi Cathy Tie David E. Hill Marc Vidal
... [+10 authors] ...,
Brenda J. Andrews
Charles Boone
Kara Dolinski
Frederick P. Roth

First Published March 14, 2016

Research

C. elegans and humans" > Extreme HOT regions are CpG-dense promoters in C. elegans and humans

Ron A.-J. Chen
Przemyslaw Stempor
Thomas A. Down
Eva Zeiser
Sky K. Feuer
Julie Ahringer

First Published March 20, 2014

Resource

C. elegans reveals promoter and enhancer architectures" > The landscape of RNA polymerase II transcription initiation in C. elegans reveals promoter and enhancer architectures

Ron A.-J. Chen
Thomas A. Down
Przemyslaw Stempor
Q. Brent Chen
Thea A. Egelhofer
LaDeana W. Hillier
Tess E. Jeffers
Julie Ahringer

First Published April 2, 2013

Research

Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans

Huriya Beyan
Thomas A. Down
Sreeram V. Ramagopalan
Kristina Uvebrant
Anita Nilsson
Michelle L. Holland Carolina Gemma Gavin Giovannoni Bernhard O. Boehm George C. Ebers
... [+5 authors] ...,
Åke Lernmark
Corrado M. Cilio
R. David Leslie
Vardhman K. Rakyan

First Published August 23, 2012

Research

A functional methylome map of ulcerative colitis

Robert Häsler
Zhe Feng
Liselotte Bäckdahl
Martina E. Spehlmann
Andre Franke
Andrew Teschendorff Vardhman K. Rakyan Thomas A. Down Gareth A. Wilson
... [+4 authors] ...,
Andrew Feber
Stephan Beck
Stefan Schreiber
Philip Rosenstiel

First Published July 23, 2012

Research

Drosophila predicts DNA methylation and CpG landscapes in other invertebrates" > Comparative methylomics reveals gene-body H3K36me3 in Drosophila predicts DNA methylation and CpG landscapes in other invertebrates

Lisa Nanty
Guillermo Carbajosa
Graham A. Heap
Francis Ratnieks
David A. van Heel
Thomas A. Down
Vardhman K. Rakyan

First Published September 22, 2011

Research

Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors

Andrew Feber
Gareth A. Wilson
Lu Zhang
Nadege Presneau
Bernadine Idowu
Thomas A. Down Vardhman K. Rakyan Luke A. Noon Alison C. Lloyd Elia Stupka Vassia Schiza
... [+6 authors] ...,
Andrew E. Teschendorff
Gary P. Schroth
Adrienne Flanagan
Stephan Beck

First Published February 1, 2011

Research

Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains

Vardhman K. Rakyan
Thomas A. Down
Siarhei Maslau
Toby Andrew
Tsun-Po Yang
Huriya Beyan Pamela Whittaker Owen T. McCann Sarah Finer
... [+4 authors] ...,
Ana M. Valdes
R. David Leslie
Panogiotis Deloukas
Timothy D. Spector

First Published March 10, 2010

Resource

C. elegans ORFeome" > Large-scale RACE approach for proactive experimental definition of C. elegans ORFeome

Kourosh Salehi-Ashtiani
Chenwei Lin
Tong Hao
Yun Shen
David Szeto
Xinping Yang Lila Ghamsari HanJoo Lee Changyu Fan Ryan R. Murray Stuart Milstein Nenad Svrzikapa
... [+7 authors] ...,
Michael E. Cusick
Frederick P. Roth
David E. Hill
Marc Vidal

First Published October 2, 2009

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