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Research

Sequence determinants of improved CRISPR sgRNA design

  • Han Xu
  • Tengfei Xiao
  • Chen-Hao Chen
  • Wei Li
  • Clifford A. Meyer
  • Qiu Wu Di Wu Le Cong
  • ... [+3 authors] ...,
  • Feng Zhang
  • Jun S. Liu
  • Myles Brown
  • X. Shirley Liu
  • First Published June 10, 2015
Research

C. elegans and humans" > Extreme HOT regions are CpG-dense promoters in C. elegans and humans

  • Ron A.-J. Chen
  • Przemyslaw Stempor
  • Thomas A. Down
  • Eva Zeiser
  • Sky K. Feuer
  • Julie Ahringer
  • First Published March 20, 2014
Resource

C. elegans reveals promoter and enhancer architectures" > The landscape of RNA polymerase II transcription initiation in C. elegans reveals promoter and enhancer architectures

  • Ron A.-J. Chen
  • Thomas A. Down
  • Przemyslaw Stempor
  • Q. Brent Chen
  • Thea A. Egelhofer
  • LaDeana W. Hillier
  • Tess E. Jeffers
  • Julie Ahringer
  • First Published April 2, 2013
Research

Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans

  • Huriya Beyan
  • Thomas A. Down
  • Sreeram V. Ramagopalan
  • Kristina Uvebrant
  • Anita Nilsson
  • Michelle L. Holland Carolina Gemma Gavin Giovannoni Bernhard O. Boehm George C. Ebers
  • ... [+5 authors] ...,
  • Åke Lernmark
  • Corrado M. Cilio
  • R. David Leslie
  • Vardhman K. Rakyan
  • First Published August 23, 2012
Research

A functional methylome map of ulcerative colitis

  • Robert Häsler
  • Zhe Feng
  • Liselotte Bäckdahl
  • Martina E. Spehlmann
  • Andre Franke
  • Andrew Teschendorff Vardhman K. Rakyan Thomas A. Down Gareth A. Wilson
  • ... [+4 authors] ...,
  • Andrew Feber
  • Stephan Beck
  • Stefan Schreiber
  • Philip Rosenstiel
  • First Published July 23, 2012
Research

Cooperation between Polycomb and androgen receptor during oncogenic transformation

  • Jonathan C. Zhao
  • Jianjun Yu
  • Christine Runkle
  • Longtao Wu
  • Ming Hu
  • Dayong Wu
  • ... [+1 authors] ...,
  • Jun S. Liu
  • Qianben Wang
  • Zhaohui S. Qin
  • Jindan Yu
  • First Published December 16, 2011
Research

Drosophila predicts DNA methylation and CpG landscapes in other invertebrates" > Comparative methylomics reveals gene-body H3K36me3 in Drosophila predicts DNA methylation and CpG landscapes in other invertebrates

  • Lisa Nanty
  • Guillermo Carbajosa
  • Graham A. Heap
  • Francis Ratnieks
  • David A. van Heel
  • Thomas A. Down
  • Vardhman K. Rakyan
  • First Published September 22, 2011
Research

Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors

  • Andrew Feber
  • Gareth A. Wilson
  • Lu Zhang
  • Nadege Presneau
  • Bernadine Idowu
  • Thomas A. Down Vardhman K. Rakyan Luke A. Noon Alison C. Lloyd Elia Stupka Vassia Schiza
  • ... [+6 authors] ...,
  • Andrew E. Teschendorff
  • Gary P. Schroth
  • Adrienne Flanagan
  • Stephan Beck
  • First Published February 1, 2011
Method

Gene expression profiling of human breast tissue samples using SAGE-Seq

  • Zhenhua Jeremy Wu
  • Clifford A. Meyer
  • Sibgat Choudhury
  • Michail Shipitsin
  • Reo Maruyama
  • Marina Bessarabova Tatiana Nikolskaya Saraswati Sukumar
  • ... [+3 authors] ...,
  • Armin Schwartzman
  • Jun S. Liu
  • Kornelia Polyak
  • X. Shirley Liu
  • First Published November 2, 2010
Research

Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains

  • Vardhman K. Rakyan
  • Thomas A. Down
  • Siarhei Maslau
  • Toby Andrew
  • Tsun-Po Yang
  • Huriya Beyan Pamela Whittaker Owen T. McCann Sarah Finer
  • ... [+4 authors] ...,
  • Ana M. Valdes
  • R. David Leslie
  • Panogiotis Deloukas
  • Timothy D. Spector
  • First Published March 10, 2010
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