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Epigenetic drift score captures directional methylation variability and links aging to transcriptional, metabolic, and genetic alterations

Xiu Fan
Qili Qian
Wenran Li
Tianzi Liu
Changqing Zeng
Peilin Jia Huandong Lin Xin Gao
... [+3 authors] ...,
Li Jin
Mingfeng Xia
Sijia Wang
Fan Liu

First Published August 1, 2025

KCNQ4" > Proactive functional classification of all possible missense single-nucleotide variants in KCNQ4

Honglan Zheng
Xinhao Yan
Guanluan Li
Hengwei Lin
Siqi Deng
Wenhui Zhuang Fuqiang Yao Yu Lu
... [+3 authors] ...,
Xin Xia
Huijun Yuan
Li Jin
Zhiqiang Yan

First Published June 27, 2022

A probabilistic method for testing and estimating selection differences between populations

Yungang He
Minxian Wang
Xin Huang
Ran Li
Hongyang Xu
Shuhua Xu
Li Jin

First Published October 13, 2015

Genome-wide detection of natural selection in African Americans pre- and post-admixture

Wenfei Jin
Shuhua Xu
Haifeng Wang
Yongguo Yu
Yiping Shen
Bailin Wu
Li Jin

First Published November 29, 2011

Complex selection on 5′ splice sites in intron-rich organisms

Manuel Irimia
Scott William Roy
Daniel E. Neafsey
Josep F. Abril
Jordi Garcia-Fernandez
Eugene V. Koonin

First Published September 10, 2009

Evolution of protein domain promiscuity in eukaryotes

Malay Kumar Basu
Liran Carmel
Igor B. Rogozin
Eugene V. Koonin

First Published January 29, 2008

Three distinct modes of intron dynamics in the evolution of eukaryotes

Liran Carmel
Yuri I. Wolf
Igor B. Rogozin
Eugene V. Koonin

First Published May 10, 2007

Evolutionarily conserved genes preferentially accumulate introns

Liran Carmel
Igor B. Rogozin
Yuri I. Wolf
Eugene V. Koonin

First Published May 10, 2007

Origins and impact of constraints in evolution of gene families

Boris E. Shakhnovich
Eugene V. Koonin

First Published October 19, 2006

Coelomata and Not Ecdysozoa: Evidence From Genome-Wide Phylogenetic Analysis

Yuri I. Wolf
Igor B. Rogozin
Eugene V. Koonin

First Published January 5, 2004

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