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Genome-wide nucleosome and transcription factor responses to genetic perturbations reveal chromatin-mediated mechanisms of transcriptional regulation

  • Kevin Moyung
  • Yulong Li
  • Heather K. MacAlpine
  • Alexander J. Hartemink
  • David M. MacAlpine
  • First Published December 9, 2025

Spatiotemporal kinetics of CAF-1-dependent chromatin maturation ensures transcription fidelity during S-phase

  • Boning Chen
  • Heather K. MacAlpine
  • Alexander J. Hartemink
  • David M. MacAlpine
  • First Published December 11, 2023

Linking the dynamics of chromatin occupancy and transcription with predictive models

  • Trung Q. Tran
  • Heather K. MacAlpine
  • Vinay Tripuraneni
  • Sneha Mitra
  • David M. MacAlpine
  • Alexander J. Hartemink
  • First Published April 23, 2021

Local nucleosome dynamics and eviction following a double-strand break are reversible by NHEJ-mediated repair in the absence of DNA replication

  • Vinay Tripuraneni
  • Gonen Memisoglu
  • Heather K. MacAlpine
  • Trung Q. Tran
  • Wei Zhu
  • Alexander J. Hartemink
  • James E. Haber
  • David M. MacAlpine
  • First Published April 2, 2021

Nascent chromatin occupancy profiling reveals locus- and factor-specific chromatin maturation dynamics behind the DNA replication fork

  • Mónica P. Gutiérrez
  • Heather K. MacAlpine
  • David M. MacAlpine
  • First Published June 19, 2019

Drosophila" > Chromatin conformation and transcriptional activity are permissive regulators of DNA replication initiation in Drosophila

  • Robin L. Armstrong
  • Taylor J.R. Penke
  • Brian D. Strahl
  • A. Gregory Matera
  • Daniel J. McKay
  • David M. MacAlpine
  • Robert J. Duronio
  • First Published October 2, 2018

Yeast genetic interaction screen of human genes associated with amyotrophic lateral sclerosis: identification of MAP2K5 kinase as a potential drug target

  • Myungjin Jo
  • Ah Young Chung
  • Nozomu Yachie
  • Minchul Seo
  • Hyejin Jeon
  • Youngpyo Nam Yeojin Seo Eunmi Kim Quan Zhong
  • ... [+4 authors] ...,
  • Marc Vidal
  • Hae Chul Park
  • Frederick P. Roth
  • Kyoungho Suk
  • First Published June 8, 2017

An extended set of yeast-based functional assays accurately identifies human disease mutations

  • Song Sun
  • Fan Yang
  • Guihong Tan
  • Michael Costanzo
  • Rose Oughtred
  • Jodi Hirschman Chandra L. Theesfeld Pritpal Bansal Nidhi Sahni Song Yi Analyn Yu Tanya Tyagi Cathy Tie David E. Hill Marc Vidal
  • ... [+10 authors] ...,
  • Brenda J. Andrews
  • Charles Boone
  • Kara Dolinski
  • Frederick P. Roth
  • First Published March 14, 2016

Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition

  • Scott A. Lujan
  • Anders R. Clausen
  • Alan B. Clark
  • Heather K. MacAlpine
  • David M. MacAlpine
  • Ewa P. Malc Piotr A. Mieczkowski
  • ... [+2 authors] ...,
  • Adam B. Burkholder
  • David C. Fargo
  • Dmitry A. Gordenin
  • Thomas A. Kunkel
  • First Published September 12, 2014

DNA replication and transcription programs respond to the same chromatin cues

  • Yoav Lubelsky
  • Joseph A. Prinz
  • Leyna DeNapoli
  • Yulong Li
  • Jason A. Belsky
  • David M. MacAlpine
  • First Published July 1, 2014
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