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Research

Sequence determinants of improved CRISPR sgRNA design

  • Han Xu
  • Tengfei Xiao
  • Chen-Hao Chen
  • Wei Li
  • Clifford A. Meyer
  • Qiu Wu Di Wu Le Cong
  • ... [+3 authors] ...,
  • Feng Zhang
  • Jun S. Liu
  • Myles Brown
  • X. Shirley Liu
  • First Published June 10, 2015
Research

C. elegans and humans" > Extreme HOT regions are CpG-dense promoters in C. elegans and humans

  • Ron A.-J. Chen
  • Przemyslaw Stempor
  • Thomas A. Down
  • Eva Zeiser
  • Sky K. Feuer
  • Julie Ahringer
  • First Published March 20, 2014
Research

Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans

  • Huriya Beyan
  • Thomas A. Down
  • Sreeram V. Ramagopalan
  • Kristina Uvebrant
  • Anita Nilsson
  • Michelle L. Holland Carolina Gemma Gavin Giovannoni Bernhard O. Boehm George C. Ebers
  • ... [+5 authors] ...,
  • Åke Lernmark
  • Corrado M. Cilio
  • R. David Leslie
  • Vardhman K. Rakyan
  • First Published August 23, 2012
Research

A functional methylome map of ulcerative colitis

  • Robert Häsler
  • Zhe Feng
  • Liselotte Bäckdahl
  • Martina E. Spehlmann
  • Andre Franke
  • Andrew Teschendorff Vardhman K. Rakyan Thomas A. Down Gareth A. Wilson
  • ... [+4 authors] ...,
  • Andrew Feber
  • Stephan Beck
  • Stefan Schreiber
  • Philip Rosenstiel
  • First Published July 23, 2012
Research

Differential DNase I hypersensitivity reveals factor-dependent chromatin dynamics

  • Housheng Hansen He
  • Clifford A. Meyer
  • Mei Wei Chen
  • V. Craig Jordan
  • Myles Brown
  • X. Shirley Liu
  • First Published April 16, 2012
Research

Drosophila predicts DNA methylation and CpG landscapes in other invertebrates" > Comparative methylomics reveals gene-body H3K36me3 in Drosophila predicts DNA methylation and CpG landscapes in other invertebrates

  • Lisa Nanty
  • Guillermo Carbajosa
  • Graham A. Heap
  • Francis Ratnieks
  • David A. van Heel
  • Thomas A. Down
  • Vardhman K. Rakyan
  • First Published September 22, 2011
Research

Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors

  • Andrew Feber
  • Gareth A. Wilson
  • Lu Zhang
  • Nadege Presneau
  • Bernadine Idowu
  • Thomas A. Down Vardhman K. Rakyan Luke A. Noon Alison C. Lloyd Elia Stupka Vassia Schiza
  • ... [+6 authors] ...,
  • Andrew E. Teschendorff
  • Gary P. Schroth
  • Adrienne Flanagan
  • Stephan Beck
  • First Published February 1, 2011
Research

Epigenetic switch involved in activation of pioneer factor FOXA1-dependent enhancers

  • Aurélien A. Sérandour
  • Stéphane Avner
  • Frédéric Percevault
  • Florence Demay
  • Maud Bizot
  • Céline Lucchetti-Miganeh Frédérique Barloy-Hubler Myles Brown
  • ... [+3 authors] ...,
  • Mathieu Lupien
  • Raphaël Métivier
  • Gilles Salbert
  • Jérôme Eeckhoute
  • First Published January 13, 2011
Research

Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains

  • Vardhman K. Rakyan
  • Thomas A. Down
  • Siarhei Maslau
  • Toby Andrew
  • Tsun-Po Yang
  • Huriya Beyan Pamela Whittaker Owen T. McCann Sarah Finer
  • ... [+4 authors] ...,
  • Ana M. Valdes
  • R. David Leslie
  • Panogiotis Deloukas
  • Timothy D. Spector
  • First Published March 10, 2010
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