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Research

Analysis of a cell-free DNA–based cancer screening cohort links fragmentomic profiles, nuclease levels, and plasma DNA concentrations

Yasine Malki
Guannan Kang
W.K. Jacky Lam
Qing Zhou
Suk Hang Cheng
Peter P.H. Cheung Jinyue Bai Ming Lok Chan Chui Ting Lee Wenlei Peng Yiqiong Zhang Wanxia Gai Winsome W.S. Wong Mary-Jane L. Ma Wenshuo Li Xinzhou Xu Zhuoran Gao Irene O.L. Tse Huimin Shang
... [+14 authors] ...,
L.Y. Lois Choy
Peiyong Jiang
K.C. Allen Chan
Y.M. Dennis Lo

First Published November 27, 2024

Research

Genomic origin, fragmentomics, and transcriptional properties of long cell-free DNA molecules in human plasma

Huiwen Che
Peiyong Jiang
L.Y. Lois Choy
Suk Hang Cheng
Wenlei Peng
Rebecca W.Y. Chan Jing Liu Qing Zhou W.K. Jacky Lam Stephanie C.Y. Yu So Ling Lau Tak Y. Leung John Wong Vincent Wai-Sun Wong
... [+9 authors] ...,
Grace L.H. Wong
Stephen L. Chan
K.C. Allen Chan
Y.M. Dennis Lo

First Published February 26, 2024

Research

Locus-resolution analysis of L1 regulation and retrotransposition potential in mouse embryonic development

Patricia Gerdes
Dorothy Chan
Mischa Lundberg
Francisco J. Sanchez-Luque
Gabriela O. Bodea
Adam D. Ewing
Geoffrey J. Faulkner
Sandra R. Richardson

First Published October 5, 2023

Research

Somatic retrotransposition in the developing rhesus macaque brain

Victor Billon
Francisco J. Sanchez-Luque
Jay Rasmussen
Gabriela O. Bodea
Daniel J. Gerhardt
Patricia Gerdes Seth W. Cheetham Stephanie N. Schauer Prabha Ajjikuttira Thomas J. Meyer Cora E. Layman Kimberly A. Nevonen Natasha Jansz Jose L. Garcia-Perez
... [+9 authors] ...,
Sandra R. Richardson
Adam D. Ewing
Lucia Carbone
Geoffrey J. Faulkner

First Published June 21, 2022

Research

A hidden layer of structural variation in transposable elements reveals potential genetic modifiers in human disease-risk loci

Elisabeth J. van Bree
Rita L.F.P. Guimarães
Mischa Lundberg
Elena R. Blujdea
Jimi L. Rosenkrantz
Fred T.G. White Josse Poppinga Paula Ferrer-Raventós Anne-Fleur E. Schneider Isabella Clayton David Haussler Marcel J.T. Reinders
... [+7 authors] ...,
Henne Holstege
Adam D. Ewing
Colette Moses
Frank M.J. Jacobs

First Published March 24, 2022

Research

L1 retrotransposition is a common feature of mammalian hepatocarcinogenesis

Stephanie N. Schauer
Patricia E. Carreira
Ruchi Shukla
Daniel J. Gerhardt
Patricia Gerdes
Francisco J. Sanchez-Luque Paola Nicoli Michaela Kindlova Serena Ghisletti Alexandre Dos Santos Delphine Rapoud Didier Samuel
... [+7 authors] ...,
Jamila Faivre
Adam D. Ewing
Sandra R. Richardson
Geoffrey J. Faulkner

First Published April 11, 2018

Research

Heritable L1 retrotransposition in the mouse primordial germline and early embryo

Sandra R. Richardson
Patricia Gerdes
Daniel J. Gerhardt
Francisco J. Sanchez-Luque
Gabriela-Oana Bodea
Martin Muñoz-Lopez J. Samuel Jesuadian Marie-Jeanne H.C. Kempen Patricia E. Carreira Jeffrey A. Jeddeloh
... [+5 authors] ...,
Jose L. Garcia-Perez
Haig H. Kazazian
Adam D. Ewing
Geoffrey J. Faulkner

First Published May 8, 2017

Research

Widespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution

Adam D. Ewing
Anthony Gacita
Laura D. Wood
Florence Ma
Dongmei Xing
Min-Sik Kim Srikanth S. Manda Gabriela Abril Gavin Pereira Alvin Makohon-Moore Leendert H.J. Looijenga Ad J.M. Gillis Ralph H. Hruban Robert A. Anders Katharine E. Romans Akhilesh Pandey Christine A. Iacobuzio-Donahue
... [+12 authors] ...,
Bert Vogelstein
Kenneth W. Kinzler
Haig H. Kazazian
Szilvia Solyom

First Published August 10, 2015

Research

Extensive somatic L1 retrotransposition in colorectal tumors

Szilvia Solyom
Adam D. Ewing
Eric P. Rahrmann
Tara Doucet
Heather H. Nelson
Michael B. Burns Reuben S. Harris David F. Sigmon Alex Casella Bracha Erlanger Sarah Wheelan Kyle R. Upton
... [+7 authors] ...,
Ruchi Shukla
Geoffrey J. Faulkner
David A. Largaespada
Haig H. Kazazian

First Published September 11, 2012