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REVIEW: Mammalian non-LTR retrotransposons: For better or worse, in sickness and in health
- Victoria P. Belancio,
- Dale J. Hedges,
- and Prescott Deininger
Genome Res. March 2008 18: 343-358; Published in Advance February 6, 2008, doi:10.1101/gr.5558208
...as boxes A and B, contain a middle A-rich region (A), and end in a poly(A) tail. SVA elements are a recently discovered hominid-specific group of retroelements that are most likely transcribed by a pol II promoter. They contain a variable number of (CCCTCT) repeats followed by an Alu -like sequence, a VNTR...
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Research: Discovery of a new repeat family in the Callithrix jacchus genome
- Miriam K. Konkel,
- Brygg Ullmer,
- Erika L. Arceneaux,
- Sreeja Sanampudi,
- Sarah A. Brantley,
- Robert Hubley,
- Arian F.A. Smit,
- and Mark A. Batzer
Genome Res. May 2016 26: 649-659; Published in Advance February 25, 2016, doi:10.1101/gr.199075.115
...and the 3′ end of an Alu element. In the latter case, the deletion may have been caused by recombination between homologous sequences. This alignment assumes that the element terminates at the middle A-rich region. An alternate alignment is provided in Supplemental Figure S4. Konkel et al. 654 Genome...
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LETTER: Novel retrotransposon analysis reveals multiple mobility pathways dictated by hosts
- Kenji Ichiyanagi,
- Ryo Nakajima,
- Masaki Kajikawa,
- and Norihiro Okada
Genome Res. January 2007 17: 33-41; Published in Advance December 6, 2006, doi:10.1101/gr.5542607
...archeology of L1 insertions in the human . Genome Biol. 3 : research0052 . ↵ Zingler, N. , Willhoeft, U. , Brose, H.P. , Schoder, V. , Jahns, T. , Hanschmann, K.M. , Morrish, T.A. , Lower, J. , Schumann, G.G. ( 2005 ) Analysis of 5′ junctions of human LINE-1 and Alu retrotransposons suggests an alternative...
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Research: Locus-resolution analysis of L1 regulation and retrotransposition potential in mouse embryonic development
- Patricia Gerdes,
- Dorothy Chan,
- Mischa Lundberg,
- Francisco J. Sanchez-Luque,
- Gabriela O. Bodea,
- Adam D. Ewing,
- Geoffrey J. Faulkner,
- and Sandra R. Richardson
Genome Res. September 2023 33: 1465-1481; Published in Advance October 5, 2023, doi:10.1101/gr.278003.123
...retrotransposition.Young L1s are rapidly methylated during in vitro mESC differentiationAs adult tissues reveal only the end point of developmental L1 methylation dynamics, we next analyzed L1 methylation at -wide and locus-specific resolution during cellular differentiation. To model various states of pluripotency...
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Research: Somatic retrotransposition in human cancer revealed by whole-genome and exome sequencing
- Elena Helman,
- Michael S. Lawrence,
- Chip Stewart,
- Carrie Sougnez,
- Gad Getz,
- and Matthew Meyerson
Genome Res. July 2014 24: 1053-1063; Published in Advance May 13, 2014, doi:10.1101/gr.163659.113
...of these elements are inactive ancient insertions, a small proportion retains its retrotransposition capacity (Brouha et al. 2003; Beck et al. 2010). The three most active retrotransposon families known are the Long INterspersed Element (LINE-1 or L1), Alu, and SVA (SINE/VNTR/ Alu) families (Moran et al. 1996...
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LETTER: L1 integration in a transgenic mouse model
- Daria V. Babushok,
- Eric M. Ostertag,
- Christine E. Courtney,
- Janice M. Choi,
- and Haig H. Kazazian, Jr.
Genome Res. February 2006 16: 240-250; Published in Advance December 19, 2005, doi:10.1101/gr.4571606
...template (Bibillo and Eickbush 2002b , 2004 ). Analogous to our results, multiple successive jumps of R2 RT can occur ( Bibillo and Eickbush 2002b ). RT template jumping was proposed to facilitate attachment of the 5′ end of R2 to the host DNA during integration ( George et al. 1996 ; Burke et al. 1999...

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