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Zichner et al. 23 (3): 568
.
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45
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Research
:
Rapid evolution of piRNA clusters in the
Drosophila melanogaster
ovary
Satyam P. Srivastav
,
Cédric Feschotte
,
and
Andrew G. Clark
Genome Res.
May 2024
34
:
711
-
724
;
Published in Advance
May 15, 2024
,
doi:
10.1101/gr.278062.123
...in
Drosophila
melanogaster
, much less is known about the origin and evolution of piCs in this or any other species. To investigate piC origin and evolution, we use a population
genomic
approach to compare piC activity and
sequence
composition across eight geographically distant strains of D.
melanogaster
...
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Research
:
Variation in the fitness impact of translationally optimal codons among animals
Florian Bénitière
,
Tristan Lefébure
,
and
Laurent Duret
Genome Res.
March 2025
35
:
446
-
458
;
Published in Advance
February 10, 2025
,
doi:
10.1101/gr.279837.124
...in an equal proportion of cytosine (C) and guanine (G), as well as an equal proportion of thymine (T) and adenine (A) (Lobry 1995). Hence, the G + C content provides good summary statistics of the
impact
of NSPs on the
genomic
base
composition. To examine the potential contribution of nonadaptive processes...
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:
Major impacts of widespread structural variation on sorghum
Zhihai Zhang
,
Joao Paulo Gomes Viana
,
Bosen Zhang
,
Kimberly K.O. Walden
,
Hans Müller Paul
,
Stephen P. Moose
,
Geoffrey P. Morris
,
Chris Daum
,
Kerrie W. Barry
,
Nadia Shakoor
,
and
Matthew E. Hudson
Genome Res.
February 2024
34
:
286
-
299
;
Published in Advance
March 13, 2024
,
doi:
10.1101/gr.278396.123
...
structural
variants (SVs), most current studies of crop genetic
variation
are dominated by single-nucleotide polymorphisms (SNPs). The extent of the
impact
of SVs on global trait
variation
, as well as their utility in -wide selection, is not yet understood. In this study, we built an SV data set
based
...
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:
T2T-CHM13 improves read mapping and detection of clinically relevant genetic variation in the Swedish population
Daniel Schmitz
,
Adam Ameur
,
and
Åsa Johansson
Genome Res.
November 2025
35
:
2377
-
2388
;
Published in Advance
September 16, 2025
,
doi:
10.1101/gr.279320.124
...in genes, independent of predicted
impact
. One-
base
pair deletions were more likely to be singletons than variants in general; 43.4% (619,334) were private to one individual, as opposed to 40% overall, but less likely to be fixed in the cohort (0.004% [170] vs. 0.036% [16,967] overall).Higher numbers...
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Mini-Review
:
A Hitchhiker's Guide to long-read genomic analysis
Medhat Mahmoud
,
Daniel P. Agustinho
,
and
Fritz J. Sedlazeck
Genome Res.
April 2025
35
:
545
-
558
;
doi:
10.1101/gr.279975.124
...methods.Two leading long-read
sequencing
technologies currently dominate the market and have significantly
impacted
the
genomics
field (Fig. 1A): Pacific Biosciences (PacBio) HiFi and Oxford Nanopore Technologies (ONT)
sequencing
. While both technologies produce continuous long reads, they present...
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:
The pig pangenome provides insights into the roles of coding structural variations in genetic diversity and adaptation
Zhengcao Li
,
Xiaohong Liu
,
Chen Wang
,
Zhenyang Li
,
Bo Jiang
,
Ruifeng Zhang
,
Lu Tong
,
Youping Qu
,
Sheng He
,
Haifan Chen
,
Yafei Mao
,
Qingnan Li
,
Torsten Pook
,
Yu Wu
,
Yanjun Zan
,
Hui Zhang
,
Lu Li
,
Keying Wen
,
and
Yaosheng Chen
Genome Res.
October 2023
33
:
1833
-
1847
;
Published in Advance
November 1, 2023
,
doi:
10.1101/gr.277638.122
...into a pan framework, and exploring their
impacts
on variability, gene expression, and adaptation at a large
population
scale
. Our findings provide novel perspectives into the previously undisclosed genetic diversity and biological underpinnings of adaptive evolution and create valuable resources...
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Research
:
Transposons contribute to the functional diversification of the head, gut, and ovary transcriptomes across
Drosophila
natural strains
Marta Coronado-Zamora
and
Josefa González
Genome Res.
September 2023
33
:
1541
-
1553
;
Published in Advance
October 4, 2023
,
doi:
10.1101/gr.277565.122
...-up analysis of gene–TE chimeras.MethodsFly stocksFive D.
melanogaster
strains obtained from the European
Drosophila
Population
Genomics
Consortium (DrosEU) were selected according to their different geographical origins: AKA-017 (Akaa, Finland), JUT-011 (Jutland, Denmark), MUN-016 (Munich, Germany), SLA-001...
Abstract
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Research
:
Rates and spectra of de novo structural mutations in
Chlamydomonas reinhardtii
Eugenio López-Cortegano
,
Rory J. Craig
,
Jobran Chebib
,
Eniolaye J. Balogun
,
and
Peter D. Keightley
Genome Res.
January 2023
33
:
45
-
60
;
Published in Advance
December 12, 2022
,
doi:
10.1101/gr.276957.122
...but a few families are silenced effectively. TE suppression may differ between CC-2931 and CC-1952 owing to genetic
variation
in genes involved in silencing pathways. Alternatively, environmental factors could
impact
TE activity. Almost nothing is known about local adaptation in C. reinhardtii, although...
Abstract
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Resource
:
Natural variation in genome architecture among 205
Drosophila melanogaster
Genetic Reference Panel lines
Wen Huang
,
Andreas Massouras
,
Yutaka Inoue
,
Jason Peiffer
,
Miquel Ràmia
,
Aaron M. Tarone
,
Lavanya Turlapati
,
Thomas Zichner
,
Dianhui Zhu
,
Richard F. Lyman
,
Michael M. Magwire
,
Kerstin Blankenburg
,
Mary Anna Carbone
,
Kyle Chang
,
Lisa L. Ellis
,
Sonia Fernandez
,
Yi Han
,
Gareth Highnam
,
Carl E. Hjelmen
,
John R. Jack
,
Mehwish Javaid
,
Joy Jayaseelan
,
Divya Kalra
,
Sandy Lee
,
Lora Lewis
,
Mala Munidasa
,
Fiona Ongeri
,
Shohba Patel
,
Lora Perales
,
Agapito Perez
,
LingLing Pu
,
Stephanie M. Rollmann
,
Robert Ruth
,
Nehad Saada
,
Crystal Warner
,
Aneisa Williams
,
Yuan-Qing Wu
,
Akihiko Yamamoto
,
Yiqing Zhang
,
Yiming Zhu
,
Robert R.H. Anholt
,
Jan O. Korbel
,
David Mittelman
,
Donna M. Muzny
,
Richard A. Gibbs
,
Antonio Barbadilla
,
J. Spencer Johnston
,
Eric A. Stone
,
Stephen Richards
,
Bart Deplancke
,
and
Trudy F.C. Mackay
Genome Res.
July 2014
24
:
1193
-
1208
;
Published in Advance
April 8, 2014
,
doi:
10.1101/gr.171546.113
...Natural
variation
in
genome
architecture among 205
Drosophila
melanogaster
Genetic Reference Panel lines Wen Huang 1 , 10 , Andreas Massouras 2 , 3 , 10 , Yutaka Inoue 4 , Jason Peiffer 1 , Miquel Ràmia 5 , Aaron M. Tarone 6...
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Research
:
Impact of the X Chromosome and sex on regulatory variation
Kimberly R. Kukurba
,
Princy Parsana
,
Brunilda Balliu
,
Kevin S. Smith
,
Zachary Zappala
,
David A. Knowles
,
Marie-Julie Favé
,
Joe R. Davis
,
Xin Li
,
Xiaowei Zhu
,
James B. Potash
,
Myrna M. Weissman
,
Jianxin Shi
,
Anshul Kundaje
,
Douglas F. Levinson
,
Philip Awadalla
,
Sara Mostafavi
,
Alexis Battle
,
and
Stephen B. Montgomery
Genome Res.
June 2016
26
:
768
-
777
;
Published in Advance
April 21, 2016
,
doi:
10.1101/gr.197897.115
...-linked and autosomal nucleotide
variation
in
Drosophila
melanogaster
and
Drosophila
simulans. Mol Biol Evol 18: 279–290. ↵Awadalla P, Boileau C, Payette Y, Idaghdour Y, Goulet JP, Knoppers B, Hamet P, Laberge C; CARTaGENE Project. 2013. Cohort profile of the CARTaGENE study: Quebec's population-
based
biobank...
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