Searching journal content for articles similar to Zhen et al. 31 (1): 110.

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  1. Method: Inferring the mode and strength of ongoing selection
    • Gustavo V. Barroso and
    • Kirk E. Lohmueller
    Genome Res. April 2023 33: 632-643; Published in Advance April 13, 2023, doi:10.1101/gr.276386.121
    ...). In humans, for example, such genetic load contributes to an ∼50% miscarriage rate (Rice 2018), most of which occur in the first 12 wk of pregnancy. Inferring the strength of selection acting on these mutations (i.e., by how much they affect fitness of homozygous carriers, measured by the selection...
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  2. Research: A-to-I RNA editing contributes to the persistence of predicted damaging mutations in populations
    • Te-Lun Mai and
    • Trees-Juen Chuang
    Genome Res. November 2019 29: 1766-1776; Published in Advance September 12, 2019, doi:10.1101/gr.246033.118
    ...is particularly strong when editing sites are located in highly important genes/loci. Examinations of deleterious missense variants from the 1000 Genomes Project further show a significantly higher proportion of rare missense mutations for G-to-A changes than for other types of changes. The proportion for G...
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  3. Research: Natural selection drives the accumulation of amino acid tandem repeats in human proteins
    • Loris Mularoni,
    • Alice Ledda,
    • Macarena Toll-Riera,
    • and M. Mar Albà
    Genome Res. June 2010 20: 745-754; Published in Advance March 24, 2010, doi:10.1101/gr.101261.109
    ..., judging by the presence of repeats of the same nature and at the same protein location in close homologs from Drosophila melanogaster and/or Caenorhabditis elegans. An additional 7% were only found in Ciona intestinalis, indicating that they had probably originated in an ancestral chordate...
  4. Research: Variation in the fitness impact of translationally optimal codons among animals
    • Florian Bénitière,
    • Tristan Lefébure,
    • and Laurent Duret
    Genome Res. March 2025 35: 446-458; Published in Advance February 10, 2025, doi:10.1101/gr.279837.124
    ...2008; dos Reis and Wernisch 2009; Galtier et al. 2018). For instance, among animals, early studies on the two main invertebrate model organisms (the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans) showed clear signatures of TS (Shields et al. 1988; Duret and Mouchiroud 1999...
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