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Zhao et al. 25 (1): 66
.
Displaying results 1-7 of
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Research
:
Profiling neural editomes reveals a molecular mechanism to regulate RNA editing during development
Suba Rajendren
,
Alfa Dhakal
,
Pranathi Vadlamani
,
Jack Townsend
,
Sarah N. Deffit
,
and
Heather A. Hundley
Genome Res.
January 2021
31
:
27
-
39
;
Published in Advance
December 18, 2020
,
doi:
10.1101/gr.267575.120
...is development-specificA major regulator of
RNA
editing in C.
elegans
is the deaminase-deficient
ADAR
protein, ADR-1 (Washburn et al. 2014; Rajendren et al. 2018). Initial studies of adr-1(-) worms identified both sites that show increased and decreased editing compared with
wild-type
worms (Tonkin et al. 2002...
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:
Genome-wide A-to-I RNA editing in fungi independent of ADAR enzymes
Huiquan Liu
,
Qinhu Wang
,
Yi He
,
Lingfeng Chen
,
Chaofeng Hao
,
Cong Jiang
,
Yang Li
,
Yafeng Dai
,
Zhensheng Kang
,
and
Jin-Rong Xu
Genome Res.
April 2016
26
:
499
-
509
;
Published in Advance
March 2, 2016
,
doi:
10.1101/gr.199877.115
...Genome-wide A-to-I
RNA
editing in fungi independent of
ADAR
enzymes Huiquan Liu 1 , Qinhu Wang 1 , Yi He 2 , Lingfeng Chen 1 , Chaofeng Hao 1 , Cong Jiang 1 , Yang Li 3 , Yafeng Dai 1 , Zhensheng Kang 1...
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:
Direct full-length RNA sequencing reveals unexpected transcriptome complexity during
Caenorhabditis elegans
development
Runsheng Li
,
Xiaoliang Ren
,
Qiutao Ding
,
Yu Bi
,
Dongying Xie
,
and
Zhongying Zhao
Genome Res.
February 2020
30
:
287
-
298
;
Published in Advance
February 5, 2020
,
doi:
10.1101/gr.251512.119
...may provide important insights into developmental processes. Finally, it holds promise to define
RNA
modifications de novo without an extra treatment step, for example, by measuring the deviation in the ion current
profile
from that of
wild-type
RNA
. Here, we performed direct
RNA
sequencing of C...
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:
The full-length transcriptome of
C. elegans
using direct RNA sequencing
Nathan P. Roach
,
Norah Sadowski
,
Amelia F. Alessi
,
Winston Timp
,
James Taylor
,
and
John K. Kim
Genome Res.
February 2020
30
:
299
-
312
;
Published in Advance
February 5, 2020
,
doi:
10.1101/gr.251314.119
...further increase the number of genes and isoforms identified, bringing this data set closer to capturing the theoretical complete C.
elegans
transcriptome.The ability to estimate poly(A) tail lengths for each read is another advantage of d
RNA
-seq. Supporting the validity of our poly(A)
profiling
approach...
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Resource
:
The
C. elegans
embryonic transcriptome with tissue, time, and alternative splicing resolution
Adam D. Warner
,
Louis Gevirtzman
,
LaDeana W. Hillier
,
Brent Ewing
,
and
Robert H. Waterston
Genome Res.
June 2019
29
:
1036
-
1045
;
Published in Advance
May 23, 2019
,
doi:
10.1101/gr.243394.118
....08.003 ↵Hashimshony T, Feder M, Levin M, Hall BK, Yanai I. 2015. Spatiotemporal transcriptomics reveals the evolutionary history of the endoderm germ layer. Nature 519: 219–222. doi:10.1038/nature13996 ↵Hundley HA, Bass BL. 2010.
ADAR
editing in double-stranded UTRs and other noncoding
RNA
sequences. Trends Biochem...
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Research
:
A-to-I RNA editing promotes developmental stage–specific gene and lncRNA expression
Boaz Goldstein
,
Lily Agranat-Tamir
,
Dean Light
,
Orna Ben-Naim Zgayer
,
Alla Fishman
,
and
Ayelet T. Lamm
Genome Res.
March 2017
27
:
462
-
470
;
Published in Advance
December 28, 2016
,
doi:
10.1101/gr.211169.116
...in gene expression upon knockout of the A-to-I
RNA
editing genes. We generated
RNA
-seq libraries from
wild-type
and
ADAR
mutant
worms grown in the same conditions. We collected the worms at the same developmental stage and compared the expression level of genes at embryo stage and L4 larval developmental...
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Research
:
A high resolution A-to-I editing map in the mouse identifies editing events controlled by pre-mRNA splicing
Konstantin Licht
,
Utkarsh Kapoor
,
Fabian Amman
,
Ernesto Picardi
,
David Martin
,
Prajakta Bajad
,
and
Michael F. Jantsch
Genome Res.
September 2019
29
:
1453
-
1463
;
Published in Advance
August 19, 2019
,
doi:
10.1101/gr.242636.118
...authors: Michael.Jantsch@meduniwien.ac.at, Konstantin.Licht@meduniwien.ac.atAbstractPre-m
RNA
-splicing and adenosine to inosine (A-to-I)
RNA
-editing occur mostly cotranscriptionally. During A-to-I editing, a genomically encoded adenosine is deaminated to inosine by adenosine deaminases acting on
RNA
(
ADARs
...
Abstract
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