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Research: SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells
- A. Rasim Barutcu,
- Bryan R. Lajoie,
- Andrew J. Fritz,
- Rachel P. McCord,
- Jeffrey A. Nickerson,
- Andre J. van Wijnen,
- Jane B. Lian,
- Janet L. Stein,
- Job Dekker,
- Gary S. Stein,
- and Anthony N. Imbalzano
Genome Res. September 2016 26: 1188-1201; Published in Advance July 19, 2016, doi:10.1101/gr.201624.115
...cells. Recently, super-enhancers, a novel type of regulatory regions having an unusual enrichment of transcription factors thatare incloseproximity,weredescribed (Whyte et al. 2013). Super-enhancers are mostly associated with developmentally regulated genes. SMARCA4 is localized at super-enhancers...
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Research: Identification of a transcriptional signature found in multiple models of ASD and related disorders
- Samuel Thudium,
- Katherine Palozola,
- Éloïse L'Her,
- and Erica Korb
Genome Res. September 2022 32: 1642-1654; Published in Advance September 14, 2022, doi:10.1101/gr.276591.122
...down-regulated signature did not yield significant GO terms through traditional GO analysis, we also performed GeneWalk (Ietswaart et al. 2021), which uses network representation learning on a combined gene-regulatory and GO-term network constructed from input genes to elucidate significant gene...

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