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  1. ...and not on experimental evidence (Supplemental Fig. S2), the gene prediction quality cannot be estimated confidently. This represents a bottleneck in the broad-scale understanding of nematode evolution and may lead to misinterpretations (Han et al. 2013). As a result, evolutionary studies across different species have so...
  2. ..., for example, among tools that solely produce protein-coding predictions.Proteome: BUSCO recoveryThe ability of a gene prediction method to recover protein-coding genes known to be conserved across a wide array of taxa is a good approximation for its ability to recover at least some subsequence of any gene...
  3. ...coexpression network analysis (WGCNA) of protein coexpression across the 251 genotypes in the two watering conditions separately (Supplemental Table S5). The two resulting networks differed in the presence of condition-specific modules indicating that water deficit has altered the structure of the protein...
  4. ...and conservative rates of evolution between species? Do similar forces act across diverse lineages as distinct as phyla? From recently completed -sequencing projects, it has been demonstrated that most multi-cellular organisms contain a similar complement of genes and gene families, owing, in part, to a common...
  5. ...in constraint is the greater contributor to ERC because it acts on all proteins. Indeed, we observe ERC proteome-wide, including between many highly conserved proteins that would only on rare occasion experience positively selected substitutions. In addition, Elyashiv et al. (2010) have used polymorphism data...
  6. ...similar to the mammalian module. Moreover, the residues involved in PAS recognition by CPSF30 and the WD40 domain of WDR33 are conserved in the homologous proteins Yth1p and Pfs2p, suggesting structural conservation of RNA binding between distant clades. Other components of the polymerase module, CPSF160...
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