Searching journal content for articles similar to Yuan et al. 12 (9): 1345.

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  1. ...result in array loss, and therefore, satDNAs mainly persist in heterochromatic regions (for review, see Lower et al. 2018). However, from our study, it appears that gene-rich euchromatin, in which recombination is expected to occur, may tolerate the accumulation of satDNA. Further, comparative analysis...
  2. ...of certain TEs (Sijen and Plasterk 2003; Slotkin et al. 2003; Bousios et al. 2016; Hung and Slotkin 2021). One such example is Mu-killer, a locus that generates smRNAs and thereby silences MuDR elements (a DNA transposon) in maize (Zea mays ssp. mays) (Slotkin et al. 2003). Mu-killer consists of a truncated...
  3. ...). These regions are essential for regulating approximately 200 imprinted genes in mammals, which are expressed in a parent-of-origin-specific manner. ICRs are emerging as “Swiss-army knife” regulatory elements that, by integrating epigenetic signals and influencing the three-dimensional (3D) chromatin structure...
  4. ...to unprocessed pseudogenes), these features suggest that the transcription of processed pseudogenes may require regulatory mechanisms distinct from canonical promoter-associated epigenetic activation. INTRODUCTION Since the release of its first draft in 2001, considerable efforts have been devoted to improving...
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  5. ...insertions and lineage-specific duplicated genes. Our findings suggest independent evolution of subterminal caps converging on a common genetic and epigenetic structure that promoted ectopic exchange as well as the emergence of novel genes at transition regions between euchromatin and heterochromatin...
  6. ...status of the D4Z4 region, the recent guideline updates (Giardina et al. 2024) have identified it as a promising option for future FSHD diagnostics. In this study, we set out to develop an all-in-one, long-read-based workflow for the genetic and epigenetic analysis of FSHD (D4Z4End2End), combining...
  7. ...of BINDER in predicting hierarchical TADs in ultrasparse Hi-C data.BINDER reveals explicit epigenetic features near hierarchical TAD boundariesEpigenetic features near TAD boundaries are a critical part of 3D genomics. A recent study suggested that chromatin would be extruded by an engaged cohesin complex...
  8. ...on libraries generated by three de novo TE tools, RM2, EDTA and REPET, which differ in their output formats, and in six species, which differ in TE content and size: the fruit fly (Drosophila melanogaster), rice (Oryza sativa), the hooded crow (Corvus cornix), zebrafish (Danio rerio), maize (Zea mays...
  9. ...), and the median region size was 448 bp (Panel 1) and 500 bp (Panel 2) (Table 1). These assembled libraries were transfected into a phNPC line derived from a female fetus of Mexican descent (Methods). The same line was used for both technical replicates for both panels. Initial quality control revealed that our...
  10. ...region may have far-reaching evolutionary consequences. Specifically, the physical proximity—or separation—of genes influences the frequency of recombination between them, thereby potentially promoting or constraining coevolution among polymorphic genes that function together in a common pathway...
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