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Yu et al. 12 (8): 1185
.
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:
Charting the regulatory landscape of TP53 on transposable elements in cancer
Xuan Qu
,
Yonghao Liang
,
Colin McCornack
,
Xiaoyun Xing
,
Heather Schmidt
,
Chad Tomlinson
,
Catrina Fronick
,
Edward A. Belter, Jr.
,
Juan F. Macias-Velasco
,
and
Ting Wang
Genome Res.
June 2025
35
:
1456
-
1471
;
Published in Advance
May 13, 2025
,
doi:
10.1101/gr.279398.124
...artifacts of incomplete transcripts derived from
intronic
SINEs (Fig. 1E; Supplemental Fig. S2A; Sela et al. 2007; Elbarbary et al. 2016; Shao and Wang 2021; Gualandi et al. 2022). Across all three transcript tiers, we observed similar subfamily enrichment, particularly with LTRs like ERV1, suggesting...
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:
Unraveling the architecture of major histocompatibility complex class II haplotypes in rhesus macaques
Nanine de Groot
,
Marit van der Wiel
,
Ngoc Giang Le
,
Natasja G. de Groot
,
Jesse Bruijnesteijn
,
and
Ronald E. Bontrop
Genome Res.
November 2024
34
:
1811
-
1824
;
Published in Advance
October 23, 2024
,
doi:
10.1101/gr.278968.124
...was followed (e.g., DRB1, DRB3). The first two or three digits designate the lineage number, whereas the digits after the first colon label the allelic variation (e.g., DRB1*01:01). A third and a fourth set of digits assign synonymous and
intronic
variations, respectively. Additional suffixes may be used...
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:
Atypical epigenetic and small RNA control of degenerated transposons and their fragments in clonally reproducing
Spirodela polyrhiza
Rodolphe Dombey
,
Daniel Buendía-Ávila
,
Verónica Barragán-Borrero
,
Laura Diezma-Navas
,
Arturo Ponce-Mañe
,
José Mario Vargas-Guerrero
,
Rana Elias
,
and
Arturo Marí-Ordóñez
Genome Res.
March 2025
35
:
522
-
544
;
Published in Advance
March 4, 2025
,
doi:
10.1101/gr.279532.124
...; Bradamante et al. 2023; Incarbone et al. 2023), and in monocots, AGO5 participates in anther development and TE silencing during male gametogenesis (Zhai et al. 2015; Fei et al. 2016; Lee et al. 2021).Regarding the RdDM pathway, Spirodela contains the
minimal
set of its components, either...
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:
Dynamic dysregulation of retrotransposons in neurodegenerative diseases at the single-cell level
Wankun Deng
,
Citu Citu
,
Andi Liu
,
and
Zhongming Zhao
Genome Res.
October 2024
34
:
1687
-
1699
;
Published in Advance
October 18, 2024
,
doi:
10.1101/gr.279363.124
...unknown. This lack of knowledge is because of the low complexity of their sequences and abundance in the (Copley and Shorter 2023), making their precise mapping of short reads to the challenging (Zhao and Han 2009; Wells and Feschotte 2020). TEs have long been categorized as “
junk
” sequences in the (Orgel...
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:
High temporal resolution RNA-seq time course data reveals widespread synchronous activation between mammalian lncRNAs and neighboring protein-coding genes
Walter Muskovic
,
Eve Slavich
,
Ben Maslen
,
Dominik C. Kaczorowski
,
Joseph Cursons
,
Edmund Crampin
,
and
Maria Kavallaris
Genome Res.
August 2022
32
:
1463
-
1473
;
Published in Advance
June 27, 2022
,
doi:
10.1101/gr.276818.122
.... This was done to remove the effects of transcription delays due to gene length. We note that, for all other analyses, pre-mRNA expression was measured using the first 10 kb of
intron
sequence from the TSS, excluding any exon sequences. Model parameters were selected as those
minimizing
the difference between...
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ARTICLE
:
A region of mouse chromosome 16 is syntenic to the DiGeorge, velocardiofacial syndrome minimal critical region.
N Galili
,
H S Baldwin
,
J Lund
,
R Reeves
,
W Gong
,
Z Wang
,
B A Roe
,
B S Emanuel
,
S Nayak
,
C Mickanin
,
M L Budarf
,
and
C A Buck
Genome Res.
January 1997
7
:
17
-
26
;
doi:
10.1101/gr.7.1.17
...A region of mouse chromosome 16 is syntenic to the DiGeorge, velocardiofacial syndrome
minimal
critical region. N Galili , H S Baldwin , J Lund , R Reeves , W Gong , Z Wang , B A Roe , B S Emanuel , S Nayak...
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Research
:
Transposons contribute to the functional diversification of the head, gut, and ovary transcriptomes across
Drosophila
natural strains
Marta Coronado-Zamora
and
Josefa González
Genome Res.
September 2023
33
:
1541
-
1553
;
Published in Advance
October 4, 2023
,
doi:
10.1101/gr.277565.122
...assembly that
minimizes
the potential sources of errors while identifying a comprehensive set of gene–TE chimeras. We applied this method to the head, gut, and ovary dissected from five Drosophila melanogaster natural strains, with individual reference s available. We found that ∼19% of body part...
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:
High resolution genomes of multiple
Xiphophorus
species provide new insights into microevolution, hybrid incompatibility, and epistasis
Yuan Lu
,
Edward Rice
,
Kang Du
,
Susanne Kneitz
,
Magali Naville
,
Corentin Dechaud
,
Jean-Nicolas Volff
,
Mikki Boswell
,
William Boswell
,
LaDeana Hillier
,
Chad Tomlinson
,
Kremitzki Milin
,
Ronald B. Walter
,
Manfred Schartl
,
and
Wesley C. Warren
Genome Res.
April 2023
33
:
557
-
571
;
Published in Advance
May 5, 2023
,
doi:
10.1101/gr.277434.122
...(623 deletions),
intronic
sequence (4990), or flanking sequence (1585). The numbers of deletions of each category and ploidy were similar across all samples, with more homozygous deletions than heterozygous in each category. This is consistent with the high homogeneity of the sampled laboratory...
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Method
:
LaSSO, a strategy for genome-wide mapping of intronic lariats and branch points using RNA-seq
Danny A. Bitton
,
Charalampos Rallis
,
Daniel C. Jeffares
,
Graeme C. Smith
,
Yuan Y.C. Chen
,
Sandra Codlin
,
Samuel Marguerat
,
and
Jürg Bähler
Genome Res.
July 2014
24
:
1169
-
1179
;
Published in Advance
April 7, 2014
,
doi:
10.1101/gr.166819.113
...for organisms like human, which generally have much larger
introns
, although the shortest human
introns
may still be affected (‘‘
minimal
’’
introns
) (Yu et al. 2002). Another issue was the aggregation of branch points next to the primary branch point that was most likely introduced by reverse...
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Research
:
Massive variation of short tandem repeats with functional consequences across strains of
Arabidopsis thaliana
Maximilian O. Press
,
Rajiv C. McCoy
,
Ashley N. Hall
,
Joshua M. Akey
,
and
Christine Queitsch
Genome Res.
August 2018
28
:
1169
-
1178
;
Published in Advance
July 3, 2018
,
doi:
10.1101/gr.231753.117
...evident functional effects. These include three of six
intronic
STR expansions we found to be associated with
intron
retention. Coding STRs were depleted of variation relative to noncoding STRs, and we detected a total of 56 coding STRs (11%) showing low variation consistent with the action of purifying...
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