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Editorial: Innovations in computational biology: RECOMB 2024 Special Issue
- Jian Ma and
- Bonnie Berger
Genome Res. September 2024 34: vii-viii; doi:10.1101/gr.280036.124
.... Genetics-driven risk predictions leveraging the Mendelian randomization framework. Genome Res (this issue) 34: 1276–1285. doi:10.1101/gr.279252.124 ↵Yang J, Yen K, Mahony S. 2024. Size-based expectation maximization for characterizing nucleosome positions and subtypes. Genome Res (this issue) 34: 1334...
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Review: Artificial intelligence and machine learning in cell-free-DNA-based diagnostics
- W.H. Adrian Tsui,
- Spencer C. Ding,
- Peiyong Jiang,
- and Y.M. Dennis Lo
Genome Res. January 2025 35: 1-19; doi:10.1101/gr.278413.123
...of ∼166 bp, reflecting the length of DNA associated with a nucleosome plus linker. Fetal- and tumor-derived cfDNA molecules exhibit a shorter modal size of ∼143 bp (Lo et al. 2010; Chandrananda et al. 2015), opening up possibilities for size-based enrichment of fetal and tumoral signals. Fragments <143 bp...
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