Searching journal content for articles similar to Yang et al. 20 (8): 1020.

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  1. ...Reuben M. Buckley and Elaine A. Ostrander National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA Corresponding author: eostrand@mail.nih.govAbstractRecent advances in genomics, coupled with a unique population structure and remarkable levels...
  2. ...QTLs identified in multiple cell types derived from the same individual (Dimas et al. 2009). eSNPs that were specific to liver were found to be enriched for the KEGG pathway drug metabolism–cytochrome P450 genes (E = 1.63 3 10#2;7, where E denotes the Bonferroni-corrected Fisher’s Exact Test [FET] P...
  3. ...pathways and can even involve the same enzymes, such as cytochromes P450 (Gao et al. 2018b; Walker et al. 2019). Therefore, it is essential to investigate the interactions between the exposome and metabolome to better understand the initial health impact of the exposome.We found 4624 statistically...
  4. ...in a proliferation of neologisms that describe their genomic manifestations rather than the underlying (and unknown) mechanisms. These include ‘‘kataegis’’: referring to a processive clustering of cytosine mutations in a TpC context oftennear genomic rearrangements, thought to be caused by DNA-editing enzymes (Nik...
  5. .... These genes included cytochrome P450s (Cyp450), flavin-containing monooxygenases, sulfotransferases, hydroxysteroid dehydrogenases, CD antigens, chemokine ligands, complement components, serum amyloids, interleukins, and various others. Most liver sexually dimorphic genes and pathways identified in previous...
  6. ...Harbor, New York 11724, USA; ↵ 6 Department of Human Genetics, Guru Nanak Dev University, Amritsar 143005, Punjab, India. Abstract In silico analyses have established that transcripts from some genes can be processed into RNAs with rearranged exon order relative to genomic structure...
  7. ...-oncogenes. Pathway enrichment 384 analysis revealed significant enrichment for the Cytochrome P450 metabolic pathway 385 (q < 0.05), which includes genes within this region such as CYP3A5 and CYP3A7. 386 Notably, CYP family enzymes can be induced by polycyclic aromatic hydrocarbons in 387 tobacco smoke, enhancing...
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  8. ...(Supplemental Table 2), we found representatives of many duplicated gene families, including drug-detoxification (glycosyltransferase family, cytochrome P450 genes), immunity (chemokine, cytokine, MLC, HLA, and defensin families), and pregnancy-related proteins. We specifically compared all possible human Ref...
  9. ...Gowrisankar 3 , Bruce J. Aronow 3 , Robert B. Weiss 2 , and Deborah A. Nickerson 1 , 4 1 Department of Genome Sciences, University of Washington, Seattle, Washington 98195-7730, USA 2 Department of Human Genetics, University of Utah, Salt...
  10. ...outside the GI tract. Several enrichments emerged with potential links to redox shifts in the small intestine. These included disulfide bonds, oxidoreductase activity, NADP, and xenobiotic metabolism through cytochrome P450s (Figs. 2, 3). Functional differences in the colon highlighted pancreatic...
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