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Yang et al. 20 (8): 1020
.
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22
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Mini-Review
:
Large-scale genomic analysis of the domestic dog informs biological discovery
Reuben M. Buckley
and
Elaine A. Ostrander
Genome Res.
June 2024
34
:
811
-
821
;
Published in Advance
July 2, 2024
,
doi:
10.1101/gr.278569.123
...Reuben M. Buckley and Elaine A. Ostrander National Human
Genome
Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA Corresponding author: eostrand@mail.nih.govAbstractRecent advances in
genomics
, coupled with a unique population structure and remarkable levels...
Abstract
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Research
:
A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort
Danielle M. Greenawalt
,
Radu Dobrin
,
Eugene Chudin
,
Ida J. Hatoum
,
Christine Suver
,
John Beaulaurier
,
Bin Zhang
,
Victor Castro
,
Jun Zhu
,
Solveig K. Sieberts
,
Susanna Wang
,
Cliona Molony
,
Steven B. Heymsfield
,
Daniel M. Kemp
,
Marc L. Reitman
,
Pek Yee Lum
,
Eric E. Schadt
,
and
Lee M. Kaplan
Genome Res.
July 2011
21
:
1008
-
1016
;
Published in Advance
May 20, 2011
,
doi:
10.1101/gr.112821.110
...QTLs identified in multiple cell types derived from the same individual (Dimas et al. 2009). eSNPs that were specific to
liver
were found to be enriched for the KEGG pathway drug metabolism–
cytochrome
P
450
genes (E = 1.63 3 10#2;7, where E denotes the Bonferroni-corrected Fisher’s Exact Test [FET] P...
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Resource
:
Precision environmental health monitoring by longitudinal exposome and multi-omics profiling
Peng Gao
,
Xiaotao Shen
,
Xinyue Zhang
,
Chao Jiang
,
Sai Zhang
,
Xin Zhou
,
Sophia Miryam Schüssler-Fiorenza Rose
,
and
Michael Snyder
Genome Res.
June 2022
32
:
1199
-
1214
;
Published in Advance
June 6, 2022
,
doi:
10.1101/gr.276521.121
...pathways and can even involve the same
enzymes
, such as
cytochromes
P
450
(Gao et al. 2018b; Walker et al. 2019). Therefore, it is essential to investigate the interactions between the exposome and metabolome to better understand the initial health impact of the exposome.We found 4624 statistically...
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Research
:
C. elegans
whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency
Bettina Meier
,
Susanna L. Cooke
,
Joerg Weiss
,
Aymeric P. Bailly
,
Ludmil B. Alexandrov
,
John Marshall
,
Keiran Raine
,
Mark Maddison
,
Elizabeth Anderson
,
Michael R. Stratton
,
Anton Gartner
,
and
Peter J. Campbell
Genome Res.
October 2014
24
:
1624
-
1636
;
Published in Advance
July 16, 2014
,
doi:
10.1101/gr.175547.114
...in a proliferation of neologisms that describe their
genomic
manifestations rather than the underlying (and unknown) mechanisms. These include ‘‘kataegis’’: referring to a processive clustering of cytosine mutations in a TpC context oftennear
genomic
rearrangements, thought to be caused by DNA-editing
enzymes
(Nik...
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LETTER
:
Tissue-specific expression and regulation of sexually dimorphic genes in mice
Xia Yang
,
Eric E. Schadt
,
Susanna Wang
,
Hui Wang
,
Arthur P. Arnold
,
Leslie Ingram-Drake
,
Thomas A. Drake
,
and
Aldons J. Lusis
Genome Res.
August 2006
16
:
995
-
1004
;
Published in Advance
July 6, 2006
,
doi:
10.1101/gr.5217506
.... These genes included
cytochrome
P
450
s (Cyp450), flavin-containing monooxygenases, sulfotransferases, hydroxysteroid dehydrogenases, CD antigens, chemokine ligands, complement components, serum amyloids, interleukins, and various others. Most
liver
sexually dimorphic genes and pathways identified in previous...
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Research
:
Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant
Haya H. Al-Balool
,
David Weber
,
Yilei Liu
,
Mark Wade
,
Kamlesh Guleria
,
Pitsien Lang Ping Nam
,
Jake Clayton
,
William Rowe
,
Jonathan Coxhead
,
Julie Irving
,
David J. Elliott
,
Andrew G. Hall
,
Mauro Santibanez-Koref
,
and
Michael S. Jackson
Genome Res.
November 2011
21
:
1788
-
1799
;
Published in Advance
September 23, 2011
,
doi:
10.1101/gr.116442.110
...Harbor, New York 11724, USA; ↵ 6 Department of Human Genetics, Guru Nanak Dev University, Amritsar 143005, Punjab, India. Abstract In silico analyses have established that transcripts from some genes can be processed into RNAs with rearranged exon order relative to
genomic
structure...
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Method
:
Nanopore sequencing identifies high-frequency somatic structural variations in laryngeal squamous cell carcinoma genomes
Xuyan Liu
,
Lin Xia
,
Yixin Qiao
,
Yang Li
,
Yan Huang
,
Bingyan Yue
,
Xi Liang
,
Xin Yang
,
Honghui Zhang
,
Jiaxun Zhang
,
Xiao Chen
,
Dan Xie
,
and
Jifeng Liu
Genome Res.
April 8, 2026
gr.281046.125
;
Published in Advance
April 8, 2026
,
doi:
10.1101/gr.281046.125
...-oncogenes. Pathway enrichment 384 analysis revealed significant enrichment for the
Cytochrome
P
450
metabolic pathway 385 (q < 0.05), which includes genes within this region such as CYP3A5 and CYP3A7. 386 Notably, CYP family
enzymes
can be induced by polycyclic aromatic hydrocarbons in 387 tobacco smoke, enhancing...
Abstract
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LETTER
:
A genome-wide survey of structural variation between human and chimpanzee
Tera L. Newman
,
Eray Tuzun
,
V. Anne Morrison
,
Karen E. Hayden
,
Mario Ventura
,
Sean D. McGrath
,
Mariano Rocchi
,
and
Evan E. Eichler
Genome Res.
October 2005
15
:
1344
-
1356
;
Published in Advance
September 16, 2005
,
doi:
10.1101/gr.4338005
...(Supplemental Table 2), we found representatives of many duplicated gene families, including drug-detoxification (glycosyltransferase family,
cytochrome
P
450
genes), immunity (chemokine, cytokine, MLC, HLA, and defensin families), and pregnancy-related proteins. We specifically compared all possible human Ref...
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ARTICLE
:
Pattern of Sequence Variation Across 213 Environmental Response Genes
Robert J. Livingston
,
Andrew von Niederhausern
,
Anil G. Jegga
,
Dana C. Crawford
,
Christopher S. Carlson
,
Mark J. Rieder
,
Sivakumar Gowrisankar
,
Bruce J. Aronow
,
Robert B. Weiss
,
and
Deborah A. Nickerson
Genome Res.
October 2004
14
:
1821
-
1831
;
Published in Advance
September 13, 2004
,
doi:
10.1101/gr.2730004
...Gowrisankar 3 , Bruce J. Aronow 3 , Robert B. Weiss 2 , and Deborah A. Nickerson 1 , 4 1 Department of
Genome
Sciences, University of Washington, Seattle, Washington 98195-7730, USA 2 Department of Human Genetics, University of Utah, Salt...
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Resource
:
Organ-level protein networks as a reference for the host effects of the microbiome
Robert H. Mills
,
Jacob M. Wozniak
,
Alison Vrbanac
,
Anaamika Campeau
,
Benoit Chassaing
,
Andrew Gewirtz
,
Rob Knight
,
and
David J. Gonzalez
Genome Res.
February 2020
30
:
276
-
286
;
Published in Advance
January 28, 2020
,
doi:
10.1101/gr.256875.119
...outside the GI tract. Several enrichments emerged with potential links to redox shifts in the small intestine. These included disulfide bonds, oxidoreductase activity, NADP, and xenobiotic metabolism through
cytochrome
P
450
s (Figs. 2, 3). Functional differences in the colon highlighted pancreatic...
Abstract
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