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Resource: Cell type–specific gene regulatory atlas prioritizes drug targets and repurposable medicines in Alzheimer's disease
- Yunxiao Ren,
- Ming Hu,
- Yang E. Li,
- Andrew A. Pieper,
- Jeffrey Cummings,
- and Feixiong Cheng
Genome Res. March 2026 36: 645-659; Published in Advance January 21, 2026, doi:10.1101/gr.280436.125
...potential therapeutic targets and drug candidates for AD.ResultsStudy designWe obtained snRNA-seq and snATAC-seq data from 84 human brain middle temporal gyrus samples provided by the Seattle Alzheimer's Disease Brain Cell Atlas (SEA-AD) study (Gabitto et al. 2024). Understanding and defining AD progression...
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Editorial: New frontiers in single-cell genomics
- Nicholas E. Navin,
- Orit Rozenblatt-Rosen,
- and Nancy R. Zhang
Genome Res. October 2021 31: ix-x; doi:10.1101/gr.276129.121
...J, Chiang C-W, Li L, Pieper AA, et al. 2021. Multimodal single-cell/nucleus RNA sequencing data analysis uncovers molecular networks between disease-associated microglia and astrocytes with implications for drug repurposing in Alzheimer's disease. Genome Res (this issue) 31: 1900–1912. doi:10...
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