Searching journal content for articles similar to Xu et al. 23 (11): 1810.

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  1. ...Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109-2218, USA; 3Section for Molecular Ecology and Evolution, Globe Institute, University of Copenhagen, 1350 Copenhagen, Denmark; 4Department of Hematology, Cell Therapy, Hemostaseology and Infectious...
  2. ...comparative analysis to the expression levels of microRNAs (miRNAs). miRNAs are small noncoding RNA (typically 22 nt) that silence mRNA post-transcriptionally and regulate biological processes such as cell growth and differentiation by functional effects on direct targets and regulatory networks (Bracken et...
  3. ...in Drosophila melanogaster, much less is known about the origin and evolution of piCs in this or any other species. To investigate piC origin and evolution, we use a population genomic approach to compare piC activity and sequence composition across eight geographically distant strains of D. melanogaster...
  4. ...it is conserved in evolution. Lists of miRNA targets found by molecular biology experiments or by computational predictions are frequently used to infer False positives in microRNA target identification Genome Research 241 www..org miRNA biological functions: Depending on prediction programs, false positive rates...
  5. ...rapidly evolved in specific lineages, and whether they contributed to adaptive evolution is still controversial. Here, using an increased number of sequenced s with high taxonomic coverage, we identified 2191 mammalian UCEs and 5938 avian UCEs from 95 mammal and 94 bird s, respectively. Our results show...
  6. ...Chromosome inactivation (XCI) in females, but some Y-linked genes were retained during the course of sex chromosome evolution, and many X-linked genes did not become subject to XCI. We reconstructed gene-by-gene dosage sensitivities on the ancestral autosomes through phylogenetic analysis of microRNA (mi...
  7. ...transcripts. Comparison with Drosophila shows that microRNA-mediated maternal transcript targeting is a conserved process in insects, but the number and sequences of microRNAs involved have diverged. The expression of fast-evolving and species-specific microRNAs in the early blastoderm of T. castaneum...
  8. ...hosts.Three main classes of animal small regulatory RNAs are microRNAs (miRNAs) and endogenous small interfering RNAs (endo-siRNAs), which range in size between 18 and 23 nt long and are typically bound by Argonaute proteins; and Piwi-interacting RNAs (piRNAs) that are bound by Piwi proteins and mainly...
  9. ...miRNA families. Notably, similar results are obtained for ancient and recent families when these are analyzed separately and using TargetScan target predictions (Supplemental Fig. S15). Genome Research 39 www..org Evolution of mammalian microRNA genes To explore the functional relevance...
  10. ...revealed thousands of sex-biased genes in mammals and birds (Yang et al. 2006; Itoh et al. 2010; Harrison et al. 2015; Melé et al. 2015). Less attention has been given to the potential impact of sex-biased microRNAs (miRNAs)—short regulatory RNAs (∼21 nt) that enable expression fine-tuning of target m...
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