Searching journal content for articles similar to Wong et al. 20 (3): 351.

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  1. Research: A CRISPR knockout screen identifies SETDB1-target retroelement silencing factors in embryonic stem cells
    • Kei Fukuda,
    • Akihiko Okuda,
    • Kosuke Yusa,
    • and Yoichi Shinkai
    Genome Res. June 2018 28: 846-858; Published in Advance May 4, 2018, doi:10.1101/gr.227280.117
    ...et al. 2015). In addition, chromatin assembly factors such as ATRX, DAXX, and CAF1A/B are also known to be involved in retroelement silencing in early embryos or embryonic stem cells (Elsasser et al. 2015; Hatanaka et al. 2015; Sadic et al. 2015; Voon et al. 2015; Yang et al. 2015).As exemplified...
  2. Research: PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX/DAXX
    • Erwan Delbarre,
    • Kristina Ivanauskiene,
    • Jane Spirkoski,
    • Akshay Shah,
    • Kristin Vekterud,
    • Jan Øivind Moskaug,
    • Stig Ove Bøe,
    • Lee H. Wong,
    • Thomas Küntziger,
    • and Philippe Collas
    Genome Res. June 2017 27: 913-921; Published in Advance March 24, 2017, doi:10.1101/gr.215830.116
    ...-9051/17; www..org Genome Research 913 www..org The ability of PML to associate with defined areas of the is supported by its interaction with telomeres in mouse embryonic stem (ES) cells, where it enables ATRX-mediated H3.3 deposition and maintenance of heterochromatin (Wong et al. 2009, 2010; Chang et al...
  3. Research: The gene repressor complex NuRD interacts with the histone variant H3.3 at promoters of active genes
    • Daniel C. Kraushaar,
    • Zuozhou Chen,
    • Qingsong Tang,
    • Kairong Cui,
    • Junfang Zhang,
    • and Keji Zhao
    Genome Res. November 2018 28: 1646-1655; Published in Advance September 25, 2018, doi:10.1101/gr.236224.118
    ...to gene silencing, such as H3K27 trimethylation and H3K9 methylation (Hake et al. 2006).Chromatin components are dynamically exchanged during and outside of DNA replication. H3.3 is deposited by histone chaperones including HIRA and the ATRX/DAXX complex, which incorporate H3.3 at regulatory sites...
  4. Research: The PML-associated protein DEK regulates the balance of H3.3 loading on chromatin and is important for telomere integrity
    • Kristina Ivanauskiene,
    • Erwan Delbarre,
    • James D. McGhie,
    • Thomas Küntziger,
    • Lee H. Wong,
    • and Philippe Collas
    Genome Res. October 2014 24: 1584-1594; Published in Advance July 21, 2014, doi:10.1101/gr.173831.114
    .... In embryonic stem cells, loss of DEK leads to relocalization of H3.3 from telomeres to chromosome arms and pericentric heterochromatin We have previously shown in mouse ESCs the role of PML in the recruitment of ATRX and H3.3 at telomeres, a process essential to maintaining telomeric chromatin integrity (Chang...
  5. Research: DAXX-dependent supply of soluble (H3.3–H4) dimers to PML bodies pending deposition into chromatin
    • Erwan Delbarre,
    • Kristina Ivanauskiene,
    • Thomas Küntziger,
    • and Philippe Collas
    Genome Res. March 2013 23: 440-451; Published in Advance December 5, 2012, doi:10.1101/gr.142703.112
    ...interaction with ASF1 or DNA (Elsasser et al. 2012). DAXX and ATRX deposit (H3.3–H4) into telomeric and pericentric chromatin (Drane et al. 2010; Goldberg et al. 2010; Lewis et al. 2010; Wong et al. 2010), and both are required for chromatin assembly and transcriptional repression of transgene arrays (Newhart...
  6. Research: Ligand-induced native G-quadruplex stabilization impairs transcription initiation
    • Conghui Li,
    • Honghong Wang,
    • Zhinang Yin,
    • Pingping Fang,
    • Ruijing Xiao,
    • Ying Xiang,
    • Wen Wang,
    • Qiuzi Li,
    • Beili Huang,
    • Jian Huang,
    • and Kaiwei Liang
    Genome Res. September 2021 31: 1546-1560; Published in Advance August 16, 2021, doi:10.1101/gr.275431.121
    ...promoter and enhancer regions (Fig. 3).Dysfunction of G4s is involved in several human diseases, such as alpha-thalassemia X-linked intellectual disability (ATR-X) syndrome, C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia (C9ALS/FTD), and breast cancer (Law et al. 2010; De...
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